French Parkinson's Disease Cohort - NS-PARK

Parkinson Disease Clinical Trial

— NS-PARK  

Official title:

Cohort of the French Clinical Research Network for Parkinson's Disease (NS-PARK Cohort)

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04888364
• Other study ID #: C16-56
• Secondary ID: 2019-A01929-48
• Status: Recruiting
• Start date: June 16, 2021
• Est. completion date: December 31, 2023

Study information

• Verified date: August 2021
• Source: Institut National de la Santé Et de la Recherche Médicale, France
• Contact: Jean Christophe MD CORVOL, PU-PH
• Phone: 33 1 42 16 57 66
• Email: jean-christophe.corvol[@]aphp.fr
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The aim of NS-PARK cohort are to describe the natural history of Parkinson's disease (PD), and to propose patients stratification models based on PD pathophysiological mechanisms. Patients are included at all PD expert centers in France. Standardized demographic, diagnosis, motor and non-motor symptoms evaluation, and treatment information are collected, and clinical data are updated at each visit of the patient at the center. A blood sampling is perform at baseline for genetic testing and implement an associated biocollection.

Description:

The national clinical research network for Parkinson's disease (NS-PARK/FCRIN) reassembles all expert centers in Parkinson's disease (PD) in France. Its aim is to promote clinical research in Parkinson's disease and movement disorder, to better understand the pathophysiology of PD, foster the development of new therapeutic strategies, and move towards personalized medicine. To help centers for prescreening, a national registry of PD patients followed in each centers has been implemented in 2016 to collect minimal relevant clinical information of patients followed in each center including demographic data, age at diagnosis, standardized motor and non-motor symptoms evaluation, and treatment. Data are updated at each visit of the patient in the center. De facto, this registry became a longitudinal cohort of PD patients followed in NS-PARK centers. In 2020, NS-PARK received funding to associate a biocollection to this clinical cohort.

The aim of NS-PARK cohort are to describe the natural history of PD progression in clinical routine in France, to develop new models of PD describing the different progression profiles, and to propose patients stratification based on PD pathophysiological mechanisms. The cohort will also serve as a platform to discover new PD genes and genetic modifiers of disease progression or response to treatment.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30000
• Est. completion date: December 31, 2023
• Est. primary completion date: August 15, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 10 Years and older

Eligibility

Inclusion Criteria:

• Diagnosis of Parkinson's disease according to UK PD brain bak criteria

• OR diagnosis of parkinsonian syndrome: multiple system atrophy, progressive supranuclear palsy, dementia with Lewy body, or corticobasal syndrom

• OR Subjects at risk of PD defined as :

No symptom or diagnosis of Parkinson's disease nor parkinsonian syndrome, and relative to a patient with a diagosis of PD or parkinsonian syndrome, or carrier of a known mutation responsible for a genetic form of PD or patient with a diagnosis of idiopathic REEM sleep disorder or prodromal form of PD as defined by MDS criteria (Berg et al., 2015)

AND for all participants

• Affiliated to social security

• Age > 10 years

Exclusion Criteria:

• Subject under legal protection

• Subject who do not consent to the research

• for the optional skin biopsy only: clinically significant coagulation abnormalities or anticoagulant treatment

Related Conditions & MeSH terms

• Parkinson Disease

Locations

Country	Name	City	State
France	Centre 01 Paris	Paris

Sponsors (1)

Lead Sponsor	Collaborator
Institut National de la Santé Et de la Recherche Médicale, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Disease progression	Hoehn and Yahr score change	through the end of follow-up in the cohort, at least 2 years, and average of 5 years
Primary	Motor and non-motor complications	Occurence of motor (dyskinesia or motor fluctuations) or non-motor (dementia, dysautonomia, behavioral or psychiatric disorders, sleep disorders, falls, ...) complication	through the end of follow-up in the cohort, at least 2 years, and average of 5 years
Primary	Modification of antiparkinsonian treatment doses	Modification of antiparkinsonian treatment during follow-up will be measured as levodopa equivalent daily doses	through the end of follow-up in the cohort, at least 2 years, and average of 5 years
Secondary	Predictive factorsof PD progression: motor or non motor symptoms	Motor or non motor symptoms as measured by MDS-UPDRS scores will be used as predictive factors for primary outcomes	through the end of follow-up in the cohort, at least 2 years, and average of 5 years
Secondary	Predictive factors of PD progression: genetic variants	Genetic variants in PD genes or the Genetic PD risk score will be used as predictive factors for primary outcomes.	through the end of follow-up in the cohort, at least 2 years, and average of 5 years
Secondary	Predictive factors of PD progression: brain imaging markers	Brain imaging makers (iron or neuromelanine content of the substantia nigra) will be used as predictive factors for primary outcomes	through the end of follow-up in the cohort, at least 2 years, and average of 5 years
Secondary	Clusters of patients with similar disease progression profiles	Clustering analyses will be performed on disease progression markers (Hoehn and Yahr score, MDS-UPDRS scores, and doses of treatment (levodopa equivalent daily doses)) to identify homogeneous groups of patients (clusters) sharing similar disease progression profiles.	through the end of follow-up in the cohort, at least 2 years, and average of 5 years
Secondary	Clusters of patients with similar genetic and disease progression profiles	Co-clustering analysis of disease progression markers (Hoehn and Yahr score, MDS-UPDRS scores, and doses of treatment (levodopa equivalent daily doses)) and genetic markers (variants in PD genes or the Genetic PD risk score).	through the end of follow-up in the cohort, at least 2 years, and average of 5 years
Secondary	Genetic mutations associated with familal forms of PD	Genetic mutations will be screened by different methods (gene panels, whole exome or whole genome) in familial forms of PD. Mutations co-segregated with PD will be considered as potentially associated with the disease.	through study completion, 15 years