Apomorphine Effects on Pain in Parkinson's Disease

Status Recruiting

Clinical Trial Summary

To study the effects of acute apomorphine vs. placebo administration on different Parkinson's disease pain types.

Clinical Trial Description

Apomorphine is the only anti-parkinsonian agent compatible with levodopa in improving Parkinson's disease (PD) motor symptoms. Besides, it has positive effects on some of the nonmotor symptoms of the disease, such as urinary disturbances and sleep. Apomorphine is usually well tolerated as it produces limited side effects. Knowledge about the effects of apomorphine on pain in PD is scarce. Evidence on this topic has only been reported in case reports or small studies but represents a potentially important use of the drug. We hypothesize that apomorphine may be a rational, safe, and useful treatment for subjects with pain in PD, including different subtypes. Within this framework, the present study will evaluate the effect of acute apomorphine vs. placebo administration on different PD pain types. ;

Study Design

Related Conditions & MeSH terms

Parkinson Disease

Clinical Trial Details

NCT number	NCT04879134
Study type	Interventional
Source	University of Calgary
Contact	Veronica Bruno, MD, MPH
Phone	403-220-7572
Email	veronica.bruno@ucalgary.ca
Status	Recruiting
Phase	Phase 2/Phase 3
Start date	February 28, 2022
Completion date	July 2023

View Details

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