Online Motor Control in People With Parkinson's Disease

Status Recruiting

Clinical Trial Summary

This study aims to better understand how people with Parkinson's control reaching movements. Specifically, we are asking how these individuals respond to different environmental perturbations. Testing includes reaching movements made within a virtual reality set-up.

Clinical Trial Description

Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting approximately up to 10 million people worldwide and with 60,000 new cases diagnosed annually in the U.S. alone. Some of the most common signs and symptoms in individuals with PD are slowed and small movements and difficulty in movement initiation. The ability to correct movements online in response to environmental changes is an important part of daily living. Online movement corrections in reaching refer to the ability to smoothly change how and where you reach in response to a change in the environment. For example, one can adjust the position of the hand and arm when trying to catch a butterfly flying in the air. Generally speaking, online movement corrections can happen in response to visual perturbations (e.g., trying to catch a butterfly) or to force perturbations (e.g., someone knocks your hand while you're holding a coffee mug). Since individuals with PD have trouble with movements, it stands to reason that they may have problems with online movement corrections. Surprisingly, very little is known about online movement corrections in individuals with PD. The current evidence suggests that individuals with PD can make online movement corrections to small visual perturbations, but whether they can successfully respond to large visual perturbations is debatable. Furthermore, whether individuals with PD can make online movement corrections to force perturbations has not been studied. The aim of this project is to investigate if individuals with PD can make online movement corrections during reaching to visual and/or force perturbations. We will test both individuals with PD and age-matched healthy controls. They will perform reaching movements while visual or force perturbations are applied. We will use various perturbation strengths in order to test for potential differences in responses to small and large perturbations. Results from this study will provide new information on how individuals with PD make online movement corrections, and possibly provide insight to improving rehabilitation for PD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04616508
Study type	Interventional
Source	University of Delaware
Contact	Hyosub Kim, PhD
Phone	302-831-4263
Email	hyosub@udel.edu
Status	Recruiting
Phase	N/A
Start date	December 12, 2018
Completion date	December 12, 2026

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.