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Clinical Trial Details — Status: Enrolling by invitation

Administrative data

NCT number NCT04560504
Other study ID # 15102717
Secondary ID
Status Enrolling by invitation
Phase N/A
First received
Last updated
Start date September 3, 2020
Est. completion date December 1, 2022

Study information

Verified date September 2022
Source The Hong Kong Polytechnic University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Parkinson's disease (PD) is a common neurodegenerative disorder which is characterized by both motor and non-motor symptoms and usually affects people aged 50 years or above. Many studies showed eye movement deficits and visual changes in patients with PD. Previous studies have also indicated that clinical eye movement training could enhance the functional performance of patients with various eye movement problems resulting from ocular and neurodegenerative diseases. In this study, we will investigate the effectiveness of eye movement training on dynamic vision and functional performance in PD patients with oculomotor deficits.


Recruitment information / eligibility

Status Enrolling by invitation
Enrollment 90
Est. completion date December 1, 2022
Est. primary completion date August 31, 2022
Accepts healthy volunteers No
Gender All
Age group 40 Years to 70 Years
Eligibility Inclusion Criteria: - Parkinson's Disease diagnosed by a neurologist or geriatrician with the range of Stage 1 to 4 (Hoehn and Yahr Classification) - Able to speak and comprehend Cantonese dialect - Able to travel independently Exclusion Criteria: - Any congenital eye problem (e.g. congenital strabismus or amblyopia in either eye) or any manifest eye diseases (e.g. macular degeneration, glaucoma, etc) - Severe medical problems (e.g. stroke) - Cognitive impairment (e.g. dementia) - Presence of any psychiatric or neurological diseases (apart from Parkinson's disease) or receiving of any psychoactive pharmacological treatment - Receiving any medication that is known to affect eye movement and cognitive function - Previous formal vision rehabilitation or oculomotor intervention

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Control Group
Leisure activities
Oculomotor Training Group
Eye movement training

Locations

Country Name City State
Hong Kong Allen MY Cheong Hong Kong

Sponsors (5)

Lead Sponsor Collaborator
The Hong Kong Polytechnic University Chinese University of Hong Kong, Deakin University, Hospital Authority, Hong Kong, University of California, Berkeley

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type Measure Description Time frame Safety issue
Primary Smooth Vergence eye movements Smooth vergence eye movement is measured using a head-mounted eye tracking while fixating at an approaching target moving at different speeds Change from baseline at week 4 and change from baseline at week 12
Secondary Oculomotor characteristics With the use of eye tracking device, eye movement behavior of participants can be measured and analysed while performing the following tasks.
Fixation task - Fixate at stationary target presented on a monitor
Saccade task - Follow and fixate at a random jumping target presented on a monitor
Pursuit task - Follow accurately and steadily on a smooth moving target presented on a monitor
Jump Vergence task - Follow and fixate a jumping target presented in the anterior-posterior plane (jumping from 'far to near' or 'near to far')
Change from baseline at week 4 and change from baseline at week 12
Secondary Sentence reading performance To evaluate the effectiveness of the interventions on sentence reading using MNREAD charts in Chinese. These charts developed in our laboratory are used to measure the effectiveness of sentence reading in terms of reading speed and critical print size. Change from baseline at week 4 and change from baseline at week 12
Secondary Passage reading performance To evaluate the effectiveness of the interventions on passage reading using International Reading speed Test (IReST). IReST is used to evaluate the effectiveness of passage reading performance by measuring the reading speed. Change from baseline at week 4 and change from baseline at week 12
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