Effectiveness of Oculomotor Training in Parkinson's Disease

Parkinson Disease Clinical Trial

Official title:

Oculomotor Deficits in Parkinson's Disease: Enhancing Eye Movement Performance and Dynamic Visual Acuity With Oculomotor Training Using a Pilot Randomized Clinical Trial Design

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT04560504
• Other study ID #: 15102717
• Status: Enrolling by invitation
• Phase: N/A
• Start date: September 3, 2020
• Est. completion date: December 1, 2022

Study information

• Verified date: September 2022
• Source: The Hong Kong Polytechnic University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Parkinson's disease (PD) is a common neurodegenerative disorder which is characterized by both motor and non-motor symptoms and usually affects people aged 50 years or above. Many studies showed eye movement deficits and visual changes in patients with PD. Previous studies have also indicated that clinical eye movement training could enhance the functional performance of patients with various eye movement problems resulting from ocular and neurodegenerative diseases. In this study, we will investigate the effectiveness of eye movement training on dynamic vision and functional performance in PD patients with oculomotor deficits.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 90
• Est. completion date: December 1, 2022
• Est. primary completion date: August 31, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 70 Years

Eligibility

Inclusion Criteria:

• Parkinson's Disease diagnosed by a neurologist or geriatrician with the range of Stage 1 to 4 (Hoehn and Yahr Classification)
• Able to speak and comprehend Cantonese dialect
• Able to travel independently

Exclusion Criteria:

• Any congenital eye problem (e.g. congenital strabismus or amblyopia in either eye) or any manifest eye diseases (e.g. macular degeneration, glaucoma, etc)
• Severe medical problems (e.g. stroke)
• Cognitive impairment (e.g. dementia)
• Presence of any psychiatric or neurological diseases (apart from Parkinson's disease) or receiving of any psychoactive pharmacological treatment
• Receiving any medication that is known to affect eye movement and cognitive function
• Previous formal vision rehabilitation or oculomotor intervention

Related Conditions & MeSH terms

• Oculomotor; Disorder
• Parkinson Disease

Intervention

Other:
• Control Group
Leisure activities
• Oculomotor Training Group
Eye movement training

Locations

Country	Name	City	State
Hong Kong	Allen MY Cheong	Hong Kong

Sponsors (5)

Lead Sponsor	Collaborator
The Hong Kong Polytechnic University	Chinese University of Hong Kong, Deakin University, Hospital Authority, Hong Kong, University of California, Berkeley

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Smooth Vergence eye movements	Smooth vergence eye movement is measured using a head-mounted eye tracking while fixating at an approaching target moving at different speeds	Change from baseline at week 4 and change from baseline at week 12
Secondary	Oculomotor characteristics	With the use of eye tracking device, eye movement behavior of participants can be measured and analysed while performing the following tasks.; Fixation task - Fixate at stationary target presented on a monitor; Saccade task - Follow and fixate at a random jumping target presented on a monitor; Pursuit task - Follow accurately and steadily on a smooth moving target presented on a monitor; Jump Vergence task - Follow and fixate a jumping target presented in the anterior-posterior plane (jumping from 'far to near' or 'near to far')	Change from baseline at week 4 and change from baseline at week 12
Secondary	Sentence reading performance	To evaluate the effectiveness of the interventions on sentence reading using MNREAD charts in Chinese. These charts developed in our laboratory are used to measure the effectiveness of sentence reading in terms of reading speed and critical print size.	Change from baseline at week 4 and change from baseline at week 12
Secondary	Passage reading performance	To evaluate the effectiveness of the interventions on passage reading using International Reading speed Test (IReST). IReST is used to evaluate the effectiveness of passage reading performance by measuring the reading speed.	Change from baseline at week 4 and change from baseline at week 12