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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03940261
Other study ID # 18-08-001
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date June 12, 2019
Est. completion date July 12, 2022

Study information

Verified date July 2022
Source University of Guelph
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Aerobic exercise is recommended for individuals with Parkinson's disease (PD) and can improve quality of life, both physically and mentally. The most efficacious program to achieve these exercise benefits is unknown. Recently, high-intensity interval training (HIIT) has been shown to be safe and more effective in many high-risk populations with limited exercise tolerance. Shorter bouts of exercise are likely better tolerated in PD due to difficulty sustaining muscle contractions. The goal of this project is to determine whether HIIT produces superior cardiorespiratory, neuromuscular, biomechanical, and clinical adaptations than conventional continuous moderate intensity training (CMIT) in PD.


Description:

The specific research aims are to compare, in PD, the effects of HIIT or CMIT on: 1) maximal exercise capacity; 2) neural and non-neural factors contributing to muscle strength, power and fatigability; 3) biomechanical measures of postural stability and gait; and 4) Clinical markers (Mini-BESTest and Unified Parkinson's Disease Rating Scale (UPDRS)). The investigators hypothesize that, HIIT will produce greater improvements in: 1) exercise capacity; 2) muscle strength, power and reduced fatigability; 3) stability and gait velocity; and 4) clinical markers. Methods: This pilot project will involve a randomized trial of 30 individuals with PD comparing the effects of HIIT and CMIT. Training will be completed thrice weekly for 10 weeks. Participants will include men and women between 50-85 years of age, who are able to stand unsupported for 1 min, walk 18m without use of an aid, and mount a stationary bike. Participants will be randomized to either HIIT (10, 1-minute cycling intervals at 90% of peak power output, each separated by 1-min at 10% peak power output) or CMIT (30-50min cycling at 60% of peak power output). Participants will undergo the following pre- and post-training assessments: Cardiovascular testing will examine hemodynamic and efferent muscle sympathetic responses to static handgrip exercise and post-exercise circulatory occlusion; Neuromuscular testing will examine muscle activity (electromyography) during voluntary and electrically stimulated contractions of the knee extensors; Biomechanical testing will examine whole-body stability, gait, and balance patterns; and Clinical risk assessments (Mini-BESTest and UPDRS).


Recruitment information / eligibility

Status Completed
Enrollment 28
Est. completion date July 12, 2022
Est. primary completion date July 12, 2022
Accepts healthy volunteers No
Gender All
Age group 45 Years to 85 Years
Eligibility Inclusion Criteria: - Men and women between 45-85 years of age - Clinical diagnosis of Parkinson disease - Able to stand unsupported for 1 minute - Able to walk 18 metres without aid - Able to mount a stationary bike Exclusion Criteria: - History of dementia - History of stroke - Type 1 diabetes - Autonomic neuropathy - Currently involved in formal exercise training (>3 day per week).

Study Design


Related Conditions & MeSH terms


Intervention

Other:
High Intensity Interval Training
Participants will complete exercise training 3x/week for 10 weeks. Exercise will consist of 10, 1-minute cycling intervals at 90% of peak power output, each separated by 1-min at 10% peak power output.
Continuous Moderate Intensity Training
Participants will complete exercise training 3x/week for 10 weeks. Exercise will consist of 30-50 minutes of cycling at 60% peak power output.

Locations

Country Name City State
Canada University of Guelph Guelph Ontario

Sponsors (3)

Lead Sponsor Collaborator
University of Guelph Parkinson Society Canada, YMCA

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Primary Maximal exercise capacity VO2 max Change from baseline following 10 weeks of aerobic exercise training
Secondary Handgrip strength Maximal handgrip strength Change from baseline following 10 weeks of aerobic exercise training
Secondary Blood Pressure Systolic and Diastolic Blood Pressure Change from baseline following 10 weeks of aerobic exercise training
Secondary Heart Rate Cardiovascular measure Change from baseline following 10 weeks of aerobic exercise training
Secondary Mini-Balance Evaluation Systems Test (Mini-BESTest) Rating scale consisting of 14 items that are each scored from 0-2, where "0" indicates the lowest level of function and "2" the highest level of function. The test has a maximum score of 28 points. Change from baseline following 10 weeks of aerobic exercise training
Secondary Unified Parkinson's Disease Rating Scale (UPDRS) We will use the rating scale to examine 3 segments. 1) MENTATION, BEHAVIOR AND MOOD - 4 questions scored between "0" and "4"; 2) ACTIVITIES OF DAILY LIVING - 13 questions scored between "0" and "4"; and 3) MOTOR EXAMINATION - 14 questions scored between "0" and "4". In each case, a score of "0" indicates normal responses. Change from baseline following 10 weeks of aerobic exercise training
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