Fox BioNet Project: ECV-003

Parkinson Disease Clinical Trial

Official title: FoxBioNet: ECV (Extracellular Vesicle) 003

Status Completed

Clinical Trial Summary

The goal of this study is to optimize pre-analytical cerebrospinal fluid (CSF) extracellular vesicle isolation protocols for increasing the detection of LRRK2 activity in human CSF

Clinical Trial Description

Specific aims to accomplish this objective are:

PRIMARY OBJECTIVES:

• To evaluate a series of extracellular vesicle isolation methods for their ability to enrich for LRRK2 and increase the detection of LRRK2 in CSF samples.

• To compare the measurements of LRRK2, p1292 LRRK2, Rabs and pRabs from the ECVs isolated using each method.

• To assess the inter-lab reliability of each method

SECONDARY OBJECTIVES

• To assess the ability of the network of sites to efficiently conduct a study involving biosample collection for PD research. Efficiency will be assessed using measures of the time taken to meet specific milestones within the study

• To assess the ability of the network to collect high quality biospecimens adhering to agreed-upon protocols.

• To gauge the willingness of participants to participate in subsequent Fox BioNet studies ;

Related Conditions & MeSH terms

• Parkinson Disease

• NCT number: NCT03775447
• Study type: Observational
• Source: Michael J. Fox Foundation for Parkinson's Research
• Status: Completed
• Start date: April 23, 2019
• Completion date: December 18, 2019