Convection Enhanced Delivery of CSF in DBS for Parkinson's

Parkinson Disease Clinical Trial

Official title: Convection Enhanced Delivery of Autologous Cerebral Spinal Fluid Improves MRI Visualizations of Basal Ganglion Nuclei During Deep Brain Stimulation Surgery

Status Completed

Clinical Trial Summary

This study will evaluate safety foremost but also the distribution and initial effectiveness of infusion-enhanced, MRI-guided DBS for patients with medication-refractory, Parkinson's disease

Clinical Trial Description

This is an open-label, single-arm, pilot study investigating the safety and feasibility of infusion-enhanced, MRI-guided DBS electrode placement. The investigators intend to enroll patients with Parkinson's disease and medically-refractory motor symptoms, who are already planned for MRI-guided DBS electrodes under general anesthesia. The hypothesis of the study is that a convective micro-infusion of autologous CSF will enhance the T2-weighted MRI visualization of the targeted nucleus during image-guided DBS surgery for Parkinson's disease. The investigators will record standard clinical measures of PD at baseline and 6 months following DBS surgery. The study will recruit patients at a rate of approximately one a month and will take less than two years to complete. ;

Related Conditions & MeSH terms

• Parkinson Disease

• NCT number: NCT03540134
• Study type: Interventional
• Source: University of Virginia
• Status: Completed
• Phase: N/A
• Start date: February 13, 2018
• Completion date: December 18, 2018