Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease.

Parkinson Disease Clinical Trial

— RTsAsMIRT  

Official title:

Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03476668
• Other study ID #: MIRT-RTs-Laterality
• Status: Completed
• Phase: N/A
• Start date: January 1, 2017
• Est. completion date: August 1, 2017

Study information

• Verified date: May 2018
• Source: Ospedale Generale Di Zona Moriggia-Pelascini
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).

Description:

To bypass the impaired habitual motor-behavioural control, Parkinson's disease (PD) patients may exploit the network of goal-directed mode of action. The frontostriatal connections underline this functioning, that is based on attention. Since the cognitive processes are related with dopamine, the asymmetrical degeneration of the dopaminergic system affects differently the right side affected (RPD) and the left side affected (LPD) PD patients.

The aim of the study was to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with PD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: August 1, 2017
• Est. primary completion date: August 1, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 85 Years

Eligibility

Inclusion Criteria:

• Stage 2.5-3 according to the Hoehn and Yahr scale (H&Y);

• Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization;

• Mini Mental State Examination (MMSE) = 24;

• No evidences of dysexecutive syndrome.

Exclusion Criteria:

• Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months;

• Drug-induced dyskinesias;

• Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III;

• Behavioral disturbances (evaluated with Neuropsychiatric Inventory);

• Visual and auditory dysfunctions according to the general clinical evaluation and medical history;

• Equivocal report about the side of disease onset or bilateral motor involvement.

Related Conditions & MeSH terms

• Attention Disturbances
• Parkinson Disease

Intervention

Other:
• MIRT
4-week multidisciplinary intensive rehabilitation treatment

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ospedale Generale Di Zona Moriggia-Pelascini

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Visual Reaction Times (V RTs)	Visual Reaction Times	4 weeks
Primary	Auditory Reaction Times (A RTs)	Auditory Reaction Times	4 weeks
Primary	Multiple Choices RTs (MC RTs)	Multiple Choices RTs	4 weeks
Secondary	Unified Parkinson's Disease Rating Scale (UPDRS)	Unified Parkinson's Disease Rating Scale	4 weeks
Secondary	Timed Up and Go Test (TUG)	Timed Up and Go Test	4 weeks