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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03004573
Other study ID # 69 HCL15_0760
Secondary ID 2016-A00143-48
Status Completed
Phase N/A
First received
Last updated
Start date March 14, 2017
Est. completion date December 13, 2019

Study information

Verified date February 2020
Source Hospices Civils de Lyon
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system, NMS), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS.


Recruitment information / eligibility

Status Completed
Enrollment 28
Est. completion date December 13, 2019
Est. primary completion date December 13, 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation

- Social insurance

Exclusion Criteria:

- No affiliation to the social insurance

- Patients under guardianship

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Neuropsychological detailed tests with focus on social cognition
MATTIS, MOCA, BREF, Light points test, PDQ39

Locations

Country Name City State
France Service de Neurologie C Hôpital " Pierre Wertheimer " Bron

Sponsors (1)

Lead Sponsor Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary variation of the emotional recognition score (point lights test) before deep brain surgery Baseline
Primary variation of the emotional recognition score (point lights test) after deep brain surgery 1 year
Secondary PDQ39 score (Parkinson's Disease Questionnaire) Quality of Life 1 year
Secondary MATTIS (dementia rating scale) score Global cognition. The Clinical Dementia Rating or CDR is a numeric scale used to quantify the severity of symptoms of dementia 1 year
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