Parkinson Disease Clinical Trial
Official title:
Functioning of the Mirror Neurons System in Parkinson's Disease and Its Impact on the Social Cognition
Verified date | February 2020 |
Source | Hospices Civils de Lyon |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system, NMS), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS.
Status | Completed |
Enrollment | 28 |
Est. completion date | December 13, 2019 |
Est. primary completion date | December 13, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation - Social insurance Exclusion Criteria: - No affiliation to the social insurance - Patients under guardianship |
Country | Name | City | State |
---|---|---|---|
France | Service de Neurologie C Hôpital " Pierre Wertheimer " | Bron |
Lead Sponsor | Collaborator |
---|---|
Hospices Civils de Lyon |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | variation of the emotional recognition score (point lights test) before deep brain surgery | Baseline | ||
Primary | variation of the emotional recognition score (point lights test) after deep brain surgery | 1 year | ||
Secondary | PDQ39 score (Parkinson's Disease Questionnaire) | Quality of Life | 1 year | |
Secondary | MATTIS (dementia rating scale) score | Global cognition. The Clinical Dementia Rating or CDR is a numeric scale used to quantify the severity of symptoms of dementia | 1 year |
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