Action-effect Anticipation in Patients With Parkinson's Disease : A Study of the Sensory Attenuation Marker.

Parkinson Disease Clinical Trial

— IDEOMOT  

Official title:

The Process of Sensory Anticipation in Patients With PARKINSON's Disease

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02894333
• Other study ID #: JBL_2014-30
• Status: Terminated
• Start date: December 2015
• Est. completion date: September 2019

Study information

• Verified date: December 2019
• Source: Fondation Ophtalmologique Adolphe de Rothschild
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The ideomotor theory of action control is considered to be central to the understanding of human voluntary action. According to the ideomotor theory, an action is represented in terms of its desired sensory effects and actions are selected by internally activating these effect representations. Recent imagery and behavioral studies showed that this anticipated representation of action-effects triggered a "sensory attenuation", meaning a decrease of perceptive performances or a decrease of sensory event-related potentials (ERP) for an expected event. Thus, the sensory attenuation constitutes a relevant behavioral tool to investigate sensory anticipation impairment in patients with Parkinson's disease. In a behavioral paradigm, patients and matched control participants have to perform a perceptive task on predicted visual action-effects mixed with mispredicted visual action effects. Performances should be better in mispredicted visual action effects for control participants only.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 1
• Est. completion date: September 2019
• Est. primary completion date: September 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Parkinson's disease

• Normal or corrected vision

Exclusion Criteria:

• Other pathology or neurological or psychiatric history

• Known pregnancy or breastfeeding

• Absence of affiliation to the French Social Security

• Person under legal protection

• Patient's opposition to participate

Related Conditions & MeSH terms

• Parkinson Disease

Intervention

Behavioral:
• behavioral observation

Locations

Country	Name	City	State
France	Fondation Adolphe de Rothschild	Paris
France	Fondation Ophtalmologique Adolphe de Rothschild	Paris

Sponsors (1)

Lead Sponsor	Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	median score	scores measured with the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS)	baseline