Resistance Training in Patients With Parkinson`s Disease.

Parkinson Disease Clinical Trial

Official title:

Effects of Resistance Training on Bradykinesia and Physical Function in Patients With Parkinson`s Disease.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02447146
• Other study ID #: RT-PD
• Status: Completed
• Phase: N/A
• First received: May 12, 2015
• Last updated: May 13, 2015
• Start date: January 2013
• Est. completion date: December 2014

Study information

• Verified date: May 2015
• Source: University of Brasilia
• Contact: n/a
• Is FDA regulated: No
• Health authority: National Health Council (http://conselho.saude.gov.br)
• Study type: Interventional

Clinical Trial Summary

This is a controlled trial to assess the effects of resistance training on bradykinesia and physical function in patients with Parkinson's Disease. Forty patients diagnosed with Parkinson Disease stage 1 to 3 of the Hoehn and Yahr scale took part in the study and were allocated into 2 groups; Training Group performed a 9-week RT program twice a week while the Control Group attended lectures on the disease.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: December 2014
• Est. primary completion date: June 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

• Medical neurologist confirmation of 1-3 Hoehn and Yahr stages,

• age between 50 and 80 years old;

• and physician attested to participate in the resistance training program.

Exclusion Criteria:

• Diagnostic of any other neurological disease, cardiovascular disease, hematologic or orthopedic disorders;

• and motor fluctuations or severe dyskinesia that could affect their ability to perform the experimental protocol.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Parkinson Disease

Intervention

Other:
• Resistance Training
The TG performed the RT program using weight machines. Before the training period, participants underwent three weeks with eight familiarization sessions to ensure proper technique execution. The protocol aimed to workout major muscle groups and involved the following exercises: chest press, knee extension, hamstrings curl, leg press, and seated row. Training sessions lasted approximately 50-60 minutes with 2 sets of 10-12 repetitions until fatigue.
• Lectures on the disease
The control group attended an orientation program with lectures on health, quality of life and scientific update on disease.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Brasilia

References & Publications (4)

Allen NE, Canning CG, Sherrington C, Fung VS. Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease. Mov Disord. 2009 Jul 15;24(9):1344-51. doi: 10.1002/mds.22609. — View Citation

Dibble LE, Hale TF, Marcus RL, Droge J, Gerber JP, LaStayo PC. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease. Mov Disord. 2006 Sep;21(9):1444-52. — View Citation

Falvo MJ, Sirevaag EJ, Rohrbaugh JW, Earhart GM. Resistance training induces supraspinal adaptations: evidence from movement-related cortical potentials. Eur J Appl Physiol. 2010 Jul;109(5):923-33. doi: 10.1007/s00421-010-1432-8. Epub 2010 Mar 21. — View Citation

Fisher BE, Wu AD, Salem GJ, Song J, Lin CH, Yip J, Cen S, Gordon J, Jakowec M, Petzinger G. The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch Phys Med Rehabil. 2008 Jul;89(7):1221-9. doi: 10.1016/j.apmr.2008.01.013. Epub 2008 Jun 13. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Bradykinesia measured with Unified Parkinson's Disease Rating Scale, section III		One time point; after the end of 9-week resistance training	No
Primary	Functional Performance measured with Ten Meters Walk Test.		One time point; after the end of 9-week resistance training	No
Secondary	Muscle strength measured with isokinetic peak torque.		One time point; after the end of 9-week resistance training	No