Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease — ICEBERG  

Parkinson Disease Clinical Trial

Official title: Etude Des Facteurs prédictifs de l'Apparition et de l'évolution de la Maladie de Parkinson

Status Recruiting

Clinical Trial Summary

Observational, prospective, monocentric study to assess clinical features, imaging and biologic biomarkers in Parkinson disease (PD) patients and rate of progression compared to healthy controls (HC) and subjects at risk to develop PD.

The primary objective of this study is to identify clinical, imaging and biologic markers of PD onset and progression for use in clinical trials of disease-modifying therapies.

Clinical Trial Description

ICEBERG will be a four-year natural history study of de novo idiopathic PD patients, healthy controls, and subjects at risk to develop PD (idiopathic Rem Behavior Disorder -iRBD, and probants of patients with PD genetically confirmed).

All subjects will be comprehensively assessed at baseline and every year thereafter. Subjects will undergo clinical (motor, neuropsychiatric, sleep, ocular and cognitive evaluations) and imaging assessments. Blood (including a DNA sample), stools, skin biopsy and cerebral spinal fluid (CSF) samples will be collected. ;

Related Conditions & MeSH terms

• Parkinson Disease

• NCT number: NCT02305147
• Study type: Observational
• Source: Institut National de la Santé Et de la Recherche Médicale, France
• Contact: Marie VIDAILHET, PhD
• Email: marie.vidailhet@psl.aphp.fr
• Status: Recruiting
• Phase: N/A
• Start date: November 6, 2014
• Completion date: November 6, 2024