Parkinson Disease Clinical Trial
— GeneparkOfficial title:
GENomic Biomarkers for PARKinson's Disease
The main goal of the GENEPARK consortium is to employ innovative haemogenomic approaches to
determine gene expression profiles specific for genetic and idiopathic Parkinson's disease
(PD) patients. These gene expression signatures will be utilised clinically as non-invasive
diagnostic tests for PD. The sensitivity of the newly developed diagnostic test will be
determined by extensive validations on an independent cohort of PD patients, whereas the
specificity will be assessed by testing patients with atypical parkinsonisms, including
multiple system atrophy, progressive supranuclear palsy and diffuse Lewy body disease. In
order to test the specificity of the diagnostic set in other disorders that affect basal
ganglia, Huntington's disease and dopa responsive dystonia patients will be analysed. The
second objective of the proposal is to determine correlations between gene expression
signatures and different stages of PD and thus provide the basis for early diagnosis and
monitoring of disease progression. These changes in blood gene expression will be correlated
with alterations detected by neuroimaging in the brain of PD patients. Such combinations of
molecular and morphological markers of disease may ultimately facilitate the selection and
monitoring of neuroprotective therapies for PD. Finally, GENEPARK aims to develop new
bioinformatic software tools for selection of genomic biomarkers using microarray data. A
set of established computational tools will be applied and novel methods, some of them based
on mechanistic modelling of the neurodegenerative diseases, will be developed in order to
study the advantages and limitations of the different methodologies.
With special emphasis on the careful clinical selection of patients and sufficient power
regarding patient numbers, as well as extensive quality control and validation of the data,
GENEPARK aims to develop a standardised approach to development and validation of
haemogenomic biomarkers of disease.
Status | Completed |
Enrollment | 219 |
Est. completion date | June 2012 |
Est. primary completion date | June 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 90 Years |
Eligibility |
Inclusion Criteria: - Diagnosis of Parkinson's disease - Ability to understand the aim of the study - Ability to sign the consent form Exclusion Criteria: - Non ability to understand the aim of the study - Non ability to sign the consent form - To be over 18 |
N/A
Country | Name | City | State |
---|---|---|---|
Croatia | Meditterranean Institute for Life Sciences | Split | |
France | INSERM Unit 679 | Paris | |
Germany | University of Lübeck and Neuroimage Nord | Lübeck | |
Germany | University Hospital Tübingen | Tübingen | |
Slovenia | University Medical Center Ljubljana | Ljubljana |
Lead Sponsor | Collaborator |
---|---|
Institut National de la Santé Et de la Recherche Médicale, France | European Union |
Croatia, France, Germany, Slovenia,
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