Parkinson Disease Clinical Trial
Official title:
Genetic Characterization of Parkinson's Disease
This study will explore the risks and causes of Parkinson's disease, a chronic progressive
nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling
gait.
Patients with Parkinson's disease, their relatives and healthy volunteers may be eligible
for this study. Candidates must be 18 years of age or older. Patients whose parkinsonism is
due to a secondary cause, such as infection or injury, and healthy volunteers who have a
first degree family member (parent, grandparent, child, sibling) with Parkinson's disease
are excluded from enrollment.
Participants are asked about possible symptoms they may have and about their general health.
They provide a blood sample to obtain DNA for genetic analysis to look for genetic
differences that might be related to risks for Parkinson's disease. White blood cells may be
treated in the laboratory to grow a cell line, which provides a source of substances in the
blood without having to draw samples repeatedly.
Status | Completed |
Enrollment | 2500 |
Est. completion date | November 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
INCLUSION CRITERIA: Individuals with Parkinson's disease OR Family members of an individual diagnosed with Parkinson's disease OR Healthy adult controls obtained through the NIH Clinical Research Volunteers Program (CVRP) or other healthy control volunteers who come forward. EXCLUSION CRITERIA: Under the age of 18 years of age OR Individuals with Parkinsonism secondary to a specific cause such as toxin exposure, birth injury, head injury, or brain infection such as encephalitis. Healthy volunteers with a medical history or first degree family history of Parkinson's disease. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003 Jan 10;299(5604):256-9. Epub 2002 Nov 21. — View Citation
Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 1998 Apr 9;392(6676):605-8. — View Citation
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997 Jun 27;276(5321):2045-7. — View Citation
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