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NCT00086073 Clinical Trial

Parkinson's Research: The Organized Genetics Initiative

Parkinson Disease Clinical Trial

— PROGENI  

Official title:
Parkinson's Disease Collaborative Study of Genetic Linkage

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00086073
Other study ID # 9703-09
Secondary ID R01NS037167
Status Completed
Phase N/A
First received June 22, 2004
Last updated February 15, 2011
Start date August 1998
Est. completion date January 2011

Study information
Verified date November 2010
Source Indiana University
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

The purpose of this trial is to study genetic and other risk factors that may be important in the development of Parkinson's disease.

Description:

The The Parkinson's Research: The Organized Genetics Initiative, also known as PROGENI, is a multi-center study involving 2000 people throughout North America who are affected, or possibly affected, with Parkinson's disease (PD). The goal of the initiative is to study the genetic and other risk factors which may be important in the development of PD.

In order to better understand the genetic factors leading to PD, researchers will study families having 2 or more members diagnosed with PD. Using DNA samples from each participant, researchers hope to identify genes that may cause a person to be at higher risk for developing PD.

Each participant in the study will be asked to complete a family history questionnaire, providing information about the history of PD in the family. Participants also will be asked to discuss the symptoms they have experienced and their responses to PD medications. This information will be used by study personnel to determine further eligibility for the study. Those eligible for further participation will be asked to undergo a study visit at the site closest to their residence, during which they will be asked to complete questionnaires regarding PD symptoms, medical history, places of residence, occupations, mood, mental status, and activity level. A blood sample will be drawn for DNA extraction. The study visit will take about 2 hours.

Recruitment information / eligibility
Status Completed
Enrollment 1800
Est. completion date January 2011
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- To be eligible to participate in this study participants must be diagnosed with or have symptoms of PD. In addition, they must also have a family history of PD in other relatives.

Exclusion Criteria:

- Subjects cannot have participated in any other genetic research project for Parkinson's disease.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Canada University of Alberta Edmonton Alberta
Canada London Health Sciences Center London Ontario
Canada Hotel-Dieu Hospital-CHUM Montreal Quebec
Canada Ottawa Civic Hospital Ottawa Ontario
Canada Toronto Western Hospital Toronto Ontario
Puerto Rico University of Puerto Rico School of Medicine San Juan
United States Albany Medical College Albany New York
United States Medical College of Georgia Augusta Georgia
United States Johns Hopkins University Baltimore Maryland
United States University of Maryland School of Medicine Baltimore Maryland
United States Parkinson's Disease & Mmvt Disorders Ctr of Boca Raton Boca Raton Florida
United States Beth Israel Deaconess Medical Center Boston Massachusetts
United States Brigham & Women's Hospital Boston Massachusetts
United States University of Buffalo Buffalo New York
United States Northwestern University Medical School Chicago Illinois
United States University of Chicago Chicago Illinois
United States University of Cincinnati Medical Center Cincinnati Ohio
United States Cleveland Clinic Foundation Cleveland Ohio
United States Ohio State University Columbus Ohio
United States UT Southwestern Medical Center Dallas Texas
United States University of Colorado Health Sciences Center Denver Colorado
United States Michigan State University East Lansing Michigan
United States Colorado Neurological Institute Englewood Colorado
United States Evanston Northwestern Healthcare Evanston Illinois
United States Parkinson's & Movement Disorder Institute Fountain Valley California
United States Pacific Health Research Institute Honolulu Hawaii
United States Baylor College of Medicine Houston Texas
United States Indiana University School of Medicine Indianapolis Indiana
United States University of Iowa Iowa City Iowa
United States University of California Irvine Irvine California
United States Mayo Clinic Jacksonville Jacksonville Florida
United States Kansas University Medical Center Kansas City Kansas
United States University of Tennessee-Health Sciences Center Memphis Tennessee
United States Medical College of Wisconsin Milwaukee Wisconsin
United States University of Minnesota Fairview Univ Med Ctr Minneapolis Minnesota
United States Institute for Neurodegenerative Disorders New Haven Connecticut
United States Oschsner Clinic Foundation New Orleans Louisiana
United States Beth Israel Medical Center New York New York
United States Columbia-Presbyterian Medical Center New York New York
United States Mount Sinai Medical Center New York New York
United States Pacific Neuroscience Medical Group, Inc Oxnard California
United States Barrow Neurological Institute Phoenix Arizona
United States University of Pittsburg Pittsburg Pennsylvania
United States Oregon Health & Science University Portland Oregon
United States University of Rochester Medical Center Rochester New York
United States University of California San Diego San Diego California
United States University of California San Francisco San Francisco California
United States Port City Neurology, Inc Scarborough Maine
United States LSU Health Sciences Center Shreveport Louisiana
United States Henry Ford Health System Southfield Michigan
United States Southern Illinois Univ School of Medicine Springfield Illinois
United States Washington University St. Louis Missouri
United States University of South Florida Tampa Florida
United States Medical College of Ohio, , Toledo Ohio
United States Neurohealth Warwick Rhode Island
United States Cleveland Clinic Florida Weston Florida
United States Cleveland Clinic Florida Weston Florida
United States Wake Forest University School of Medicine Winston-Salem North Carolina

Sponsors (4)
Lead Sponsor Collaborator
Indiana University School of Medicine Children's Hospital Medical Center, Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), The Parkinson Study Group

Countries where clinical trial is conducted

United States,  Canada,  Puerto Rico, 

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