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Paravertebral Block clinical trials

View clinical trials related to Paravertebral Block.

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NCT ID: NCT06426706 Recruiting - Clinical trials for Regional Anesthesia Morbidity

TPVB or SPSIPB in Pain Management After VATS

Start date: May 15, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare the analgesic efficacy of thoracal paravertebral block (TPVB) and serratus posterior superior intercostal plane block (SPSIPB) in patients undergoing video-assisted thoracoscopic surgery (VATS). The main questions it aims to answer are: How will the total perioperative opioid consumption of the patients receiving two different blocks change? How will TPVB and SPSIPB effect the patients' numeric rating scores for pain in the postoperative 24-hour period? How will TPVB and SPSIPB effect the incidence of opioid related side effects? Participants will be divided in two groups: TPVB group will receive a TPVB before the surgery. SPSIPB group will receive a SPSIPB nerve block before the surgery. Researchers will compare the results between the groups to see the postoperative effects concerning opioid consumption as well as the pain scores, respiratory parameters and opioid associated side effects. The hypothesis of this study is that participants receiving SPSIPB for VATS will have a less total opioid consumption 24 hours postoperatively.

NCT ID: NCT06231355 Recruiting - Analgesia Clinical Trials

Liposomal vs. Conventional Bupivacaine for Pain Control

Start date: February 21, 2024
Phase: Phase 4
Study type: Interventional

The goal of this pilot study is to test the hypothesis that liposomal bupivacaine extends the duration of paravertebral block in patients undergoing radical nephrectomy, achieving improved analgesia compared to conventional bupivacaine. The main questions it aims to answer are: - Area under curve of numeric rating scale of pain from 12 to 72 h after surgery. - Cumulative opioid consumption during the period of 12 to 72 h after surgery.

NCT ID: NCT06082206 Not yet recruiting - Chronic Pain Clinical Trials

Pectoral Nerve Block Versus Paravertebral Block In The Incidence of Chronic Pain After Mastectomy:

Start date: November 2023
Phase: N/A
Study type: Interventional

Chronic pain after Mastectomy is frequent and an important healthcare priority because of its effect on quality of life. Although the association between the severity of acute pain after surgery and the likelihood of chronic pain is known, their causal relationship has not been clarified. Mastectomy, frequently done for the management of breast cancer, is associated with significant acute postoperative pain and limited shoulder movement.

NCT ID: NCT06011746 Completed - Chronic Pain Clinical Trials

Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy

Start date: August 30, 2023
Phase: Phase 4
Study type: Interventional

To evaluate the role of adding ketamine to levobupivacaine in PVB on acute and chronic pain in thoracotomy

NCT ID: NCT05896150 Recruiting - Thoracic Surgery Clinical Trials

Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection

CRYO-VATS
Start date: November 9, 2023
Phase: N/A
Study type: Interventional

Intercostal cryoanalgesia is a technique that allows extensive and prolonged analgesia of the hemithorax. The aim of this study is to demonstrate the efficacy of intercostal cryoanalgesia as an adjunct to a single-injection paravertebral block for the management of acute thoracic pain after VATS lung resection surgery.

NCT ID: NCT05822076 Enrolling by invitation - Paravertebral Block Clinical Trials

Influence of Thoracic Paravertebral Block on Cardiac Repolarization

Start date: February 2, 2023
Phase:
Study type: Observational

Aim of the study is to determine the presence and direction of electrocardiographical changes of cardiac repolarization after thoracic paravertebral block, depending on block laterality. Injection of local anaesthetic into paravertebral space (paravertebral block, PVB) temporarily impairs transmission in nerve fibers in proximity of the deposition site. In case of PVB covering the rami of upper thoracic spinal nerves, among the others thoracic sympathetic cardiac nerves are blocked, possibly affecting action potential time of heart, especially the repolarization, and the related electrocardiographic phenomena. The risk of life-threatening polymorphic ventricular tachycardia (torsade des pointes, TdP) is associated with certain electrocardiographical symptoms, like QT interval prolongation and increased transmural repolarization dispersion (TDR). Determining the presence and direction of cardiac repolarization changes after a thoracic PVB will allow to conclude about its impact on TdP risk: protective or, contrary, arrhythmogenic.

NCT ID: NCT05816538 Not yet recruiting - Breast Cancer Clinical Trials

The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks

Start date: April 2023
Phase: N/A
Study type: Interventional

The use of regional anesthesia in breast surgery improves the postoperative outcome, reduces the development of infection, and weakens the perioperative immunosuppressive response associated with the response to surgical stress. The investigators hypothesize that the use of propofol / paravertebral anesthesia and analgesia will be accompanied by a decrease in serum proinflammatory cytokines and/or an increase in anti-inflammatory cytokines compared to propofol / PECS 2 anesthesia and analgesia. The research will be on 100 respondents divided into two groups. 0.5% levobupivacaine will be administered to both groups. Serum concentrations of pro- and anti-inflammatory cytokines, and lymphocyte subpopulations 1h before, 24h, and 48h after surgery will be measured. The investigators aim to compare the effect of propofol / paravertebral and propofol / PECS 2 anesthesia and analgesia on serum perioperative values of pro-inflammatory and anti-inflammatory cytokines to standardize protocols and apply the best method of perioperative analgesia in breast cancer surgery.

NCT ID: NCT05713643 Completed - Analgesia Clinical Trials

ESPB vs PVB vs QLB After Pelvi-ureteric Surgeries

Start date: January 30, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to compare the analgesic efficacy of erector spinae plane block versus thoracic paravertebral block versus quadratus lumborum block on postoperative analgesia after pelvi-ureteric surgeries.

NCT ID: NCT04304274 Completed - Analgesia Clinical Trials

Programmed Intermittent Bolus Infusion of Thoracic Paravertebral Block for Hepatectomy

Start date: March 10, 2020
Phase: N/A
Study type: Interventional

Hepatectomy induces moderate to severe postoperative pain. Patient-controlled intravenous analgesia has been used in many medical centers for post-hepatectomy analgesia, but the effects are limited and often cause undesirable adverse effects. Regional Block has been used for postoperative analgesia in many surgeries. Some studies suggest that regional analgesia has an opioid-sparing effect and can reduce the incidence of chronic pain. Also, the programmed intermittent bolus infusion is better than continuous infusion, with less analgesic consumption and fewer adverse effects. Studies on the early and late postoperative analgesia and recovery effects of paravertebral block for open hepatectomy are scarce. Therefore, the investigators aim to conduct a prospective, randomized, subject and assessor-blinded, parallel-group, placebo-controlled study to test the hypothesis that the programmed intermittent bolus infusion of right thoracic paravertebral block reduces postoperative intravenous analgesic use and pain scores and improved patients' satisfaction.

NCT ID: NCT04078347 Completed - Paravertebral Block Clinical Trials

Infrared Thermography to Evaluate the Effect of Paravertebral Block

Start date: October 1, 2019
Phase:
Study type: Observational

The aim of this prospective observational study was to evaluate the changes of skin temperature after the paravertebral block measured by infrared thermography.