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Clinical Trial Summary

This is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent administered intravenously in participants with advanced solid tumors that are antigen-rich.


Clinical Trial Description

This Phase 1/2 study consists of two parts: Phase 1 Dose Escalation and Phase 2 Dose Expansion. In Phase 1 Dose Escalation, STAR0602 will be administered intravenously in participants with advanced solid tumors to assess safety/tolerability profile of STAR0602 and to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of STAR0602. In Phase 2 Dose Expansion, STAR0602 at RP2D will be administered to participants with advanced, antigen-rich solid tumors to further evaluate safety and assess preliminary clinical activity of STAR0602. Clinical activity will be evaluated by objective tumor response rate (ORR), duration of response (DOR), disease control rate (DCR), and progression free survival (PFS). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05592626
Study type Interventional
Source Marengo Therapeutics, Inc.
Contact Ke Liu, MD, PhD
Phone +1 (617) 917-4980
Email kliu@marengotx.com
Status Recruiting
Phase Phase 1/Phase 2
Start date January 4, 2023
Completion date October 2026

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