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Pancreatitis, Chronic clinical trials

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NCT ID: NCT01142128 Terminated - Clinical trials for Chronic Pancreatitis

Viokase 16, Viokase16 Plus Nexium and Nexium Alone

AZ
Start date: February 2009
Phase: Phase 1
Study type: Interventional

Our primary hypothesis is that the addition of Nexium to Viokase 16 will decrease the chronic abdominal pain in patients with small duct chronic pancreatitis in a superior fashion compared to Viokase 16 plus placebo or to Nexium alone. A secondary hypothesis would be an increase in quality of life. Our objective is to elucidate the role of Nexium in the control of pancreatic pain, quality of life, and narcotic usage alone or when added to Viokase 16. Our endpoints are the reduction of abdominal pain, decreased pain medication usage, decreased ER visits and decreased hospital admissions for abdominal pain.

NCT ID: NCT01141998 Completed - Clinical trials for Chronic Pancreatitis

Vitamin D Substitution for Patients With Chronic Pancreatitis and Malabsorption

Start date: December 2009
Phase: N/A
Study type: Interventional

Purpose: The overall objective of this study is to learn more about the disease chronic pancreatitis and thus contribute to better treatments. The investigators will gain this by studying the effects of vitamin D in the body immune system and bones. The investigators will also study the uptake of vitamin D through the intestine compared with the amount of vitamin D obtained through exposure to UVB rays. The investigators have set a series of questions which the investigators want to answer with this experiment: Do patients with chronic pancreatitis have reduced absorption of vitamin D from the gut? - Have the two treatment methods with vitamin D, UV radiation and tablets, the same success rate? - Does the distribution of the white blood cells change when the vitamin D level increases and does it depend on whether the patient have UVB radiation or tablet with vitamin D? - Will patients require reduced amounts of painkillers when vitamin D level increases? - Does vitamin D have influence on blood sugar and thus the risk of diabetes or worsening of this? - Could vitamin D affect the blood content of inflammation markers? - Does the patient feel better when he takes vitamin D? - Does bone strength increase when the patients receive grants of vitamin D?

NCT ID: NCT01138124 Completed - Hypertension Clinical Trials

Gabapentin and Risk of Pancreatic Cancer and Renal Cancer (GPRD)

Start date: March 2010
Phase: N/A
Study type: Observational

High doses of gabapentin are associated with pancreatic acinar cell tumors in rats, but there has been no post marketing pancreatic carcinogenicity signal with gabapentin as reported by spontaneous reports in the Adverse Events Reporting System or in the published literature. In a published case-control screening study of the association of gabapentin with 55 cancers, the only cancer that met the screening criteria for possibly increased cancer risk with gabapentin exposure was renal (including renal pelvis) cancer. This association was judged to be likely due to or substantially accentuated by confounding by cigarette smoking, hypertension, and lifestyle (Cancer Causes Control 2009;20:1821-1835). The primary objective of this study is to determine whether exposure to gabapentin is associated with an increased risk of developing pancreatic cancer or renal cancer in the United Kingdom (UK) General Practice Research Database (GPRD). Almost all members of the UK population are registered with a General Practice, which centralizes the medical information not only from the general practitioners themselves but also from specialist referrals and hospital attendances. Over 487 General Practices contribute data to the GPRD. The study cohort from which cases and controls are drawn is all subjects in the GPRD 1993-2008. Gabapentin was approved in the UK in May 1993. Entry into the study cohort begins Jan 1, 1993 for all those who are registered in GPRD before that time, and at the time of registration if later than Jan 1, 1993. Patients with a first diagnosis of the respective cancer 1995-2008 are risk set matched with up to 10 controls within the same General Practice for age at cohort entry (within two years), sex, and year of entry into the study cohort (within one year). For cases, the index date is the date of first diagnosis of the respective cancer. The index date for controls is set as the date at which the follow-up time from cohort entry is the same as the case. The index date is chosen so as to give the control equal follow-up time to that of the case for ascertainment of use of gabapentin. Cases and controls will be required to have at least 2 years of follow-up in the study cohort before their index date. Data on gabapentin prescriptions are obtained for cases and controls from study cohort entry to the index date. Crude and adjusted odds ratios and 95% confidence intervals (CI) will be produced from conditional logistic regression models, with additional analyses evaluating for latency and dose-response. For pancreatic cancer, covariates are smoking, body mass index, diabetes, epilepsy, neuropathic pain, and chronic pancreatitis. For renal cancer, covariates are smoking, body mass index, diabetes, hypertension, diuretic use, epilepsy, and neuropathic pain.

NCT ID: NCT01085747 Unknown status - Clinical trials for Chronic Pancreatitis

Endoscopic Treatment of Biliary Stricture Caused by Chronic Pancreatitis

Start date: March 2008
Phase: N/A
Study type: Observational

Benign biliary strictures can be endoscopically treated with plastic or self-expandable metal stents (SEMS). The purpose of the prospective randomized study is to compare the safety and feasibility of covered SEMS with multiple plastic stents in the treatment of benign biliary stricture caused by chronic pancreatitis.

NCT ID: NCT01059669 Recruiting - Clinical trials for Chronic Pancreatitis

The Diagnosis of Chronic Pancreatitis

Start date: August 2009
Phase: N/A
Study type: Observational

To develop a new standardized multimodal diagnostic approach to CP considering: WP 1: Fat in faeces and functional testing; the combination of tests has to be easy to practice, should take as little time as possible and discomfort for the patient has to be minimized WP 2: Advanced ultrasonography and imaging modalities. The focus is on validating standard parenchymal, contrast enhanced and functional ultrasound compared to a modern imaging standard. (CT, EUS, MRI) To evaluate the reliability and feasibility of these novel methods in healthy volunteers; AND To compare findings in known severe CP patients and different stages of pancreatic insufficiency in patients with CP.

NCT ID: NCT01005017 Recruiting - Chronic Pain Clinical Trials

Percutaneous Lesioning Splanchnic Nerves in Patients With Chronic Pancreatitis

PRFLSN
Start date: February 2011
Phase: N/A
Study type: Interventional

Chronic pancreatitis is a progressive inflammatory disease resulting in slow destruction of the pancreas. This chronic inflammation can lead to chronic abdominal pain which can last for many years. Unfortunately, medical management often is of only limited benefit in treating the pain of chronic pancreatitis. Management of patients with intractable pain is difficult, often resulting in narcotic addiction. Early results in a small group of patients suggest that percutaneous radiofrequent lesioning of splanchnic nerves has good potential for pain control in a subset of patients with chronic pancreatitis. Given the simplicity of the procedure, it clearly warrants reappraisal to identify its current role in pancreatic pain management.

NCT ID: NCT01001923 Terminated - Clinical trials for Abdominal Pain Upper

Single Injection of REGN475/SAR164877 in the Treatment of Chronic Pancreatitis Pain

Start date: December 2009
Phase: Phase 2
Study type: Interventional

Primary objective was to demonstrate the activity of REGN475/SAR164877 in reducing the pain associated with chronic pancreatitis. Secondary objectives were: - to assess the safety and tolerability of REGN475/SAR164877 in patients with chronic pancreatitis pain; - to characterize the pharmacokinetic, pharmacodynamic, and immunogenicity profiles of REGN475/SAR164877 in this population; - to measure the change in the total daily dose of rescue medications required.

NCT ID: NCT00957151 Completed - Clinical trials for Chronic Pancreatitis

Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis

Start date: April 2004
Phase: Phase 4
Study type: Interventional

The objective is to evaluate the dietary nitrogen assimilation and metabolic utilisation capability of patients with chronic pancreatitis.

NCT ID: NCT00956839 Completed - Clinical trials for Pancreatitis, Chronic

Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis

Start date: July 2009
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine the efficacy of 2 different doses of intramuscular (IM) vitamin D3 as compared to an oral replacement dose in normalizing vitamin D levels in the blood of patients with tropical calcific pancreatitis.

NCT ID: NCT00909103 Completed - Clinical trials for Pancreatic Adenocarcinoma

Endoscopic Ultrasound Elastography in Pancreatic Masses

EUS-EG
Start date: June 2008
Phase: N/A
Study type: Observational

The aim of the study is to assess elastography during EUS examinations of focal pancreatic masses, and to consequently differentiate benign versus malignant pancreatic masses in a prospective multi-center design.