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Effects of Sustained-release Oral Sodium Nitrite on Postoperative Pain and Recovery Following Total Knee Arthroplasty

Pain Clinical Trial

Official title:
Effects of Sustained-release Oral Sodium Nitrite Supplementation on Pain-related Outcomes and Peri- and Postoperative Physiology in People Undergoing Unilateral All-component Revision Total Knee Arthroplasty

Clinical Trial Summary

This study will determine whether a drug called sodium nitrite helps improve pain and post-operative recovery associated with knee replacement surgery.

Clinical Trial Description

The goal of this study is to examine the potential for oral sodium nitrite supplementation to reduce postoperative pain and inflammation and improve functional recovery in individuals undergoing unilateral revision total knee replacement. A sustained release formulation of sodium nitrite (40 mg) administered twice daily will be compared with placebo for a 30-day treatment period. Primary objectives are to evaluate pain and markers of functional improvement. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05893160
Study type Interventional
Source University of Alabama at Birmingham
Contact Shanna H Graves
Phone 205-975-2845
Email shannagraves@uabmc.edu
Status Not yet recruiting
Phase Phase 1
Start date August 1, 2024
Completion date August 1, 2026
View Details
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