Pain Clinical Trial
Official title:
Efficacy of Dexketoprofen Prescribed According to the Circadian Rhythms
Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus. In order to minimize disconfort after extraction, analgesic and anti-inflammatory medication is prescribed. Recently, it is seen that circadian rhythm may play an important role on drugs metabolism, modulating its effect depending on the moment of administration. The aim of the study is to analyze if dosage modification of a Non Steroideal Anti-Inflammatory (dexketoprofen) affects on postoperative pain, swelling and open mouth limitation according the circadian clock
Status | Not yet recruiting |
Enrollment | 10 |
Est. completion date | November 1, 2023 |
Est. primary completion date | July 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - Bilateral impacted lower third molar Exclusion Criteria: - NSAID allergic - Contraindication of surgery |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Universidad Complutense de Madrid | McGill University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Trismus | Open mouth limitation in milimiters, interincisal distance | Baseline and post operatory (day 1, day 3 and day 7) | |
Other | Inflammatory profile for IL-1B, IL-6, IL-8, IL-10, TNF alpha | Blood sample analysis for inflammatory cytokines in IU/ml by ELISA test (enzyme-linked immunoassay) | Baseline, day 3 and day 7 | |
Primary | Post operatory pain | Postoperatory pain with Visual Analogue Scale (VAS: 0 (no pain) to 10 (worst pain)) | From the day of the surgical procedure to the seventh-day | |
Secondary | Swelling | Distance from tragus to pogonion | Baseline and post operatory (day 1, day 3, day 7) |
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