Pain Clinical Trial
Official title:
A Comparison of Oral Controlled-release Morphine With Transdermal Fentanyl in Nasopharyngeal Cancer Patients With Moderate or Severe Oral Mucositis Pain Induced by Chemoradiotherapy
The primary purpose of this study is to explore the significance of analgesic treatment for radiation-induced oral mucositis pain in patients with nasopharyngeal carcinoma during radiotherapy, and to compare the analgesic effect of morphine controlled-release tablets with that of fentanyl transdermal patch. Half of participants will receive morphine controlled-release tablets,while the other half will receive fentanyl transdermal patch.
Morphine controlled-release tablets and fentanyl transdermal patch each relieve
radiation-induced oral mucositis pain in patients with nasopharyngeal carcinoma. But they do
so by different mechanisms and in different effects.
Morphine is a classic strong analgesic, which has been widely used in patients with advanced
cancer pain. It has achieved satisfactory results in pain control, sleep improvement and
quality of life. Oral morphine has been regarded as the standard treatment for moderate and
severe cancer pain.
Fentanyl transdermal patch is a system device for transdermal delivery of drugs. It is
compressed on a film containing fentanyl memory. The film can continuously release fentanyl
into the blood circulation and maintain stable for more than 72 hours. It is not affected by
gastrointestinal PH or food, and it has no hepatic frst-pass effect, with a bioavailability
of up to 92%.
This study will test the efficacy and safety of morphine controlled-release tablets compared
to fentanyl transdermal patch in the treatment of pain in patients with radiation-induced
oral mucositis.
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