Stellate Ganglion Block in Herpes Zoster

Pain Clinical Trial

Official title:

Utility of Early Serial Stellate Ganglion Block in Acute Herpes Zoster of Face and Neck

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04188327
• Other study ID #: 33426/10/10
• Status: Recruiting
• Phase: N/A
• Start date: May 1, 2020
• Est. completion date: October 1, 2024

Study information

• Verified date: April 2024
• Source: Tanta University
• Contact: Sohair Soliman, Professor
• Phone: 00201283929049
• Email: sohairsoliman[@]hotmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Patient who will be presented to Tanta University Hospitals complaining of acute herpes zoster with onset of vesicular eruption less than 7 days will be included in this clinical study. Patients will be excluded if they refused participation, had allergy to local anesthetics, coagulopathy, local infection, glaucoma, or neurological deficit. All the patients will receive acyclovir (antiviral therapy) and pregablin (analgesic) and the patients will be classified into two groups:- Group I (control group): Patients will receive sham block weekly for three times Group III (SGB group): Patients will receive stellate ganglion block weekly for three times The time of first block after the onset of vesicular eruption, the incidence of PHN, NPRS at visit, duration of acute HZ , duration of PHN (if occurred), and the incidence of complication will be measured.

Description:

This prospective randomized study will be carried out on adult patients complaining of acute herpes zoster presented at Tanta University Hospitals after approval from ethics committee for twelve months. An informed consent will be taken from each patient. All data of patients will be confidential with secret codes and private file for each patient. All given data will be used for the current medical research only. Any unexpected risk encountered during the course of the research will be cleared to the participant as well as to the Ethical Committee on time. Every patient will receive an explanation to the purpose of the study and will have a secret code number to ensure privacy of the participants and confidentiality of their data. The study will be terminated in case of incidence of severe hypotension no responding to ephedrine (Mean arterial blood pressure less than 60 mmHg) or severe bradycardia not responding to atropine (Heart rate less than 40 b/min). The participants and the ethical committee will be announced. There will be adequate supervision to maintain the privacy of patients and confidentiality of data. There will be no conflict of interest, nor conflict with religion, law, or society standards. The research will be beneficial to the society and has no risk of environmental pollution. After inclusion, adequate history taking, clinical examination, and laboratory investigation (as needed) will be done for all patients. Every patient will be educated about the use of the 0-10 numerical rating scale for pain assessment (NPRS: with endpoints of 'no pain' and 'worst pain'). Each patient will receive: - Acyclovir 800 mg orally every 5 times per day (for immuno-compromised patients 10 mg/kg IV 3 times per day) for 7 days. - Pregabalin start with 50 mg orally every 8hours for 7 days then increase to 150 mg every 12 hours Groups: Participants will be divided into two groups; each group consists of (88) patients. The sample size calculation was made using Epi-Info software program created by the WHO - Group I (control group): Patients will receive sham block weekly for three times - Group II (SGB group): Patients will receive stellate ganglion block weekly for three times Equipment - 10-mL syringe - For local anesthetic - 22- or 25-gauge, 1.5-inch short-bevel needle - Skin temperature monitor - Ultrasound machine with a 6-12 MHz linear type probe. - Appropriate equipment and medications for medical resuscitation Technique of SGB: The patient will be positioned supine with slight neck extension and rotation to the contralateral side. After adequate asepsis of the neck, the probe will be placed perpendicular to tracheal axis at the cricoid cartilage. An initial scan will be obtained to identify structures: thyroid gland, carotid artery and jugular vein. The transverse process at C6 should be identified as the initial landmark because of its prominent anterior tubercle (The Chassaignac tubercle). The long muscle of the neck (longus colli) is found above it. The puncture should be in-plane to see the tip of the needle all the time. The needle will be directed medially until it passes through the deep cervical fascia above the longus colli muscle. Considering repeated aspiration test, a 7 ml injectate (for SGB group: 6ml bupivicain 0.25%+ 1 ml methylpredinosolone 40mg) will be done while observing the dissection between the carotid artery and the longus colli muscle. After finishing the block: The patient will be transferred to the recovery room for 30-60 min to assess any potential complications. After that he will be discharged. Review appointments will be arranged weekly for 4 weeks then every 2 weeks for 4 months.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: October 1, 2024
• Est. primary completion date: October 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 60 Years to 85 Years

Eligibility

Inclusion Criteria:

• Patients who is presented to the pain clinic, diagnosed with acute herpes zoster of the face and/ or neck with onset of vesicular eruption less than seven days

Exclusion Criteria:

• Patient refusal or un-cooperation
• Known history of allergy to local anesthetics
• Local infection at the site of the block
• Platelet count less than 75,000/ cc
• Neurological deficit in the upper limb
• Glaucoma
• Bradycardia

Related Conditions & MeSH terms

• Ganglion Cysts
• Herpes Zoster
• Neuropathic
• Pain

Intervention

Procedure:
• Stellate ganglion block
While the patient is in a supine position with slight neck extension and rotation to the contralateral side, in-plane ultrasound guided stellate ganglion block will be performed with injection of 7 ml injectate (6ml bupivicain 0.25%+ 1 ml methylpredinosolone 40mg). Each patient will receive: Acyclovir 800 mg orally every 5 times per day 7 days. Pregabalin start with 50 mg orally every 8hours for 7 days then increase to 150 mg every 12 hours
• Sham Stellate ganglion block
The patient will be positioned supine with slight neck extension and rotation to the contralateral side. Under US guidance, a sham stellate ganglion block will be performed with injection of a 1ml injectate of normal saline will be done while observing the dissection between the carotid artery and the longus colli muscle. Each patient will receive: Acyclovir 800 mg orally every 5 times per day for 7 days. Pregabalin start with 50 mg orally every 8hours for 7 days then increase to 150 mg every 12 hours

Locations

Country	Name	City	State
Egypt	Faculty of Medicine	Fayoum
Egypt	Faculty of Medicine	Tanta	Algharbia
Egypt	Tanta University hospitals	Tanta

Sponsors (2)

Lead Sponsor	Collaborator
Tanta University	Mohamad Gamal Elmawy, M.D

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of Post-herpetic neuralgia	The incidence of chronic neuropathic pain in the face or the neck after herpes zoster	within 3 months of the last stellate ganglion block
Secondary	The duration of herpes zoster	The time from diagnosis of HZ till resolving of it	Through study completion, an average of 1 year