Pain Clinical Trial
Official title:
Intravenous Lidocaine Versus Provider Chosen Dose of Morphine for the Treatment of Severe Pain in the Emergency Department: An Open-label Randomized Controlled Pilot Study
Objective: Evaluate the analgesic efficacy of intravenous (IV) lidocaine versus provider
chosen dose of IV morphine for the treatment of severe pain in the emergency department.
Study design: Open-label, randomized controlled pilot study.
Objective: The purpose of this pilot study is to determine the analgesic efficacy of
intravenous lidocaine versus morphine for the treatment of severe pain in the emergency
department (ED).
Study design: Open-label, randomized, controlled pilot trial. Participants: Investigators and
research assistants will recruit patients ≥18 years old with severe pain (NRS ≥7) and an
anticipated stay in the emergency department ≥1 hour. A sample size calculation was performed
and 32 patients will be enrolled.
Intervention: After a trained research assistant obtains written informed consent, eligible
participants will be randomized to the intravenous lidocaine or morphine arms of the study.
In the intravenous lidocaine arm, patients will receive IV lidocaine (75 mg if <50kg, 100 mg
if 50 - 100 kg, and 150 mg if >100 kg) over 10 minutes in a 100 mL normal saline minibag
followed by a 50 minute IV lidocaine drip (75 mg if <50kg, 100 mg if 50 - 100 kg, and 150 mg
if >100 kg). In the morphine arm, the ED provider will choose an appropriate dose of morphine
for the patient. At 20 and 40 minutes, the participants will be asked "Would you like
additional pain medication?". Participants responding in the affirmative will receive
morphine 4 mg IV.
Data collection: The trained research assistant will collect data on the patients' pain
scores, side effects, and rescue morphine.
Statistical analysis: Investigators will perform descriptive statistics and compare pain
scores and pain relief at each time point with unpaired t-tests.
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