Pain Clinical Trial
Official title:
Two Dose Epidural Morphine for Post-cesarean Analgesia
The investigators aim to assess the analgesic effect of a two-dose epidural morphine regimen for 2nd day post-cesarean pain, as part of a multimodal analgesia regimen, which includes scheduled Nonsteroidal anti-inflammatory drugs (NSAIDs). The investigators hypothesize that administration of a second dose of epidural morphine 3 mg, 24 hours after an initial intraoperative dose, will provide superior post-cesarean analgesia during the 2nd 24 hours after surgery, compared to a single epidural morphine dose regimen. The primary outcome will be the amount of intravenous morphine patients self-administer during the 2nd 24 hours post-surgery.
This will be a randomized, double-blinded placebo-controlled study. In this study, women who
underwent cesarean section with epidural anesthesia will receive 3 mg of epidural morphine
intraoperatively, and have the epidural catheter left in place. Patients will be randomized
to receive either epidural saline or epidural morphine 3 mg at 18 - 24 hours after the first
dose of epidural morphine, following which the epidural catheter will be removed. It is
standard of care at our institution for women undergoing cesarean section with epidural
anesthesia to receive epidural morphine 3 mg. What is not typically carried out is to give a
second dose of epidural morphine 3mg.
The randomization will be carried out by a computerized block randomization table; the
proportion for the 2 groups will be 1:1. The primary outcome will be the amount of
intravenous morphine patients self-administer in the second 24 hours after surgery.
Secondary outcomes will include pain scores every 6 hours, satisfaction with analgesia, side
effects (itching, nausea/vomiting).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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