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Visualisation of the Central Analgesic Effect of Paracetamol in Functional MRI — IRMf  

Pain Clinical Trial

Official title:
Visualisation of the Central Analgesic Effect of Paracetamol in Functional MRI

Clinical Trial Summary

Paracetamol is one of the most widely used analgesic in the world, indicated for the symptomatic treatment of fever and pain. The objective of this study is to evaluate the mechanism of action of paracetamol (versus placebo) in the brain with new assessment tools (functional MRI and test inducing pain by thermal stimulation.

Clinical Trial Description

Visit 1 / Visit 2 Inclusion of the subject, Clinical examination Trainings tests

Study period 1 Clinical examination Measurement of the basal pain thresholds Administration of product (T0) T0+100min : Thermal stimulation according to the established paradigm and fMRI data acquisition T0+180min : Thermal stimulation according to the established paradigm and fMRI data acquisition

Study period 2: same of period 1. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01562704
Study type Interventional
Source University Hospital, Clermont-Ferrand
Contact
Status Completed
Phase Phase 1
Start date January 2012
Completion date April 2012
View Details
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