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Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia

Pain Clinical Trial

Official title:
Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia in Patients Undergoing Thoracotomy During Anesthesia Recovery Period

Clinical Trial Summary

Dexmedetomidine is a highly selective α2 adrenoreceptor agonist approved by the US FDA for short-term postoperative sedation and analgesia.It can also reduce the stress response without respiratory depression.

In this prospective, randomized, double-blind, placebo-controlled study，we gave dexmedetomidine or saline placebo 1h before operations were over and assessed the effects of dexmedetomidine on stress response and postoperative analgesia in patients undergoing thoracotomy during anesthesia recovery period.

Clinical Trial Description

Dexmedetomidine can significantly reduce the emergence agitation and postoperative pain in patients who received chest surgery ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01517932
Study type Interventional
Source Huazhong University of Science and Technology
Contact
Status Completed
Phase Phase 4
Start date June 2011
Completion date December 2011
View Details
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