Pain Clinical Trial
Official title:
Metabolism and Toxicity of Acetaminophen in Preterm Infants
The purpose of this study is to investigate how acetaminophen (APAP) is released into the urine and blood; to determine how the blood levels of acetaminophen and its breakdown products affect the preterm infant's health; to decrease adverse drug reactions; and to collect data on how the genetic make-up or characteristics affect how APAP is handled within the preterm infant. By taking several blood and urine samples during the study, we will be able to check the blood levels (called pharmacokinetics) of APAP in preterm babies.
Study procedures: The decision to replace standard intravenous morphine therapy with APAP will be made by the attending neonatologist. Length of participation: 60 hours. No patient will be prescribed the medication specifically for the study purposes in the study protocol. ;
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