Pain Clinical Trial
Official title:
Intravenous Magnesium Infusion for Pain Relief After Thoracotomy. A Randomized Controlled Trial.
All patients were premedicated with oral midazolam 5-15 mg. one hour before surgery. General anesthesia with double lumen endobronchial tube was given. Patient was induced by propofol and fentanyl. Cisatracurium was given to facilitate intubation. Patient was ventilated with 50% oxygen in air. Anesthesia was maintained with propofol and fentanyl in order to keep blood pressure and heart rate within 20% of the baseline. Cisatracurium was given every 30 minutes in order to control ventilation. At the end of surgery, neuromuscular blockade was reversed.In PACU, the I.V. PCA machine was connected to the patient. The setting of PCA was basal infusion of morphine 1 mg/hr bolus of morphine 1 mg with lockout interval 5 minutes and 4-hour limit 30 mg.The patient's mean arterial blood pressure, heart rate were recorded before induction, before intubation, at 15, 15, 30, 60, 90 and 120 minutes after intubation, and at 4, 8,16 and 24 h after surgery. The total amounts of fentanyl, propofol and magnesium sulphate were recorded. The time between the cessation of magnesium sulphate and extubation was recorded. The amounts of morphine usage at 4, 8, 16 and 24 hours after surgery were recorded. Pain score was evaluated at rest and deep breath and sedation score at 1, 2, 3, 4, 8, 16 and 24 hours after surgery using numeric rating scale (NRS). Sedation score was graded as 0 = fully awake, 1 = somnolence, responds to call, 2 = somnolence, responds to tactile stimulation, 3 = asleep, responds to painful stimulation. The times that the patient first sipping, taking food, sitting at the edge of bed and walk with help were also recorded. The side effects such as nausea, vomiting, pruritus and respiratory depression were recorded. Cost effective analysis was also evaluated.
All patients were premedicated with oral midazolam 5-15 mg. one hour before surgery. In the
operating room, each patient was monitored with noninvasive blood pressure, ECG and pulse
oximetry. After the patient was anesthetized, direct blood pressure, end-tidal carbon
dioxide tension (ETCO2) and esophageal temperature were monitored. Choice of anesthesia was
general anesthesia with double lumen endobronchial tube (Bronchocath). Patient was induced
by propofol 1.5-2.5 mg/kg and fentanyl 2 μg/kg. After the patient was unconscious,
cisatracurium 0.2 mg/kg was given to facilitate intubation. Patient was ventilated with 50%
oxygen in air. Anesthesia was maintained with propofol 6 -12 mg/kg/hr and 1 μg/kg of
fentanyl was given intermittently every 1-1.5 hour in order to keep blood pressure and heart
rate within 20% of the baseline. Cisatracurium (0.03 mg/kg) was given every 30 minutes in
order to control ventilation. The patient was ventilated with volume controlled ventilator.
Throughout the surgery, the ETCO2 was kept between 30-35 mmHg. During two lung ventilation,
the airway pressure was kept within 20 cmH2O and respiratory rate 10-12 beats/minute. One
lung ventilation was achieved with airway pressure less than 30 cmH2O and respiratory rate
12-20 beats/minute. During the surgery, the lower part of the patient was warmed with forced
air warmer (Bier Hugger) At the end of surgery, neuromuscular blockade was reversed by
prostigmine 2.5 mg and atropine 1.2 mg.
In the post anesthesia care unit, the I.V. PCA machine was connected to the patient. The
setting of PCA was basal infusion of morphine 1 mg/hr bolus of morphine 1 mg with lockout
interval 5 minutes and 4-hour limit 30 mg. The patient's mean arterial blood pressure, heart
rate were recorded before induction, before intubation, at 15, 15, 30, 60, 90 and 120
minutes after intubation, and at 4, 8 , 16 and 24 hour after surgery. The total amounts of
fentanyl, propofol and magnesium sulphate were recorded. The time between the cessation of
magnesium sulphate and extubation was recorded. The amounts of morphine usage at 4, 8, 16
and 24 hours after surgery were recorded. Pain score was evaluated at rest and deep breath
and sedation score at 1, 2, 3, 4, 8, 16 and 24 hours after surgery using numeric rating
scale (NRS). Sedation score was graded as 0 = fully awake, 1 = somnolence, responds to call,
2 = somnolence, responds to tactile stimulation, 3 = asleep, responds to painful
stimulation. The times that the patient first sipping, taking food, sitting at the edge of
bed and walk with help were also recorded. The side effects such as nausea, vomiting,
pruritus and respiratory depression were recorded. Cost effective analysis was also
evaluated.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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