Clinical Trial Details
— Status: Terminated
Administrative data
| NCT number |
NCT01201213 |
| Other study ID # |
2007AN01 |
| Secondary ID |
|
| Status |
Terminated |
| Phase |
Phase 4
|
| First received |
September 13, 2010 |
| Last updated |
May 29, 2017 |
| Start date |
September 2009 |
| Est. completion date |
August 2012 |
Study information
| Verified date |
May 2017 |
| Source |
NHS Tayside |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
A need exists to define the best local anesthetic and technique for pain relief in early
labour. We suggest that calculating the molar Median Effective Dose for bupivacaine,
levobupivacaine and ropivacaine given both by the intrathecal (as a combined spinal epidural
and epidural routes) would provide a valid comparison between the pain relieving properties
of all three drugs, from which a reasoned assessment of side effects can be made.
Description:
Despite 40 years of epidural analgesia, a consensus still does not exist regarding the best
local anesthetic or the best technique for the provision of pain relief in early labour. Two
new local anesthetics, levobupivacaine and ropivacaine, have recently been introduced into
clinical practice because they have shown reductions in cardiovascular and cerebrovascular
toxicity in several small animal, large animal and human volunteer studies. Evidence of
improved safety from these studies suggest that the new local anesthetics should be used for
surgical anesthesia, such as cesarean section, and limb block, where large volume, high
concentrations of local anesthetics are required, and the risk of toxicity is high.
In contrast, the use of levobupivacaine and ropivacaine in small doses for analgesia in
labour remains controversial, and bupivacaine remains the intrathecal and extradural local
anesthetic of choice in many obstetric units. A change from bupivacaine to one of the newer
drugs for analgesia in labour would require evidence documenting a distinct advantage of one
the new local anesthetics in providing equivalent pain relief, but with less side effects.
Until now, intrathecal and epidural studies investigating the efficacy of bupivacaine,
levobupivacaine and ropivacaine in obstetric anesthesia have focused on a comparison of %
weight/volume solutions. However, close scrutiny of the chemical composition of local
anaesthetics with the same % weight/volume shows marked differences in molar concentration.
The reason for differences in molar concentration are two-fold. Levobupivacaine is presented
commercially as a base and not as a hydrochloride and therefore has 12.7% more molecules
than the equivalent concentration of bupivacaine. In addition, ropivacaine has a smaller
molecular weight than either drug and thus has 4.5% more molecules than bupivacaine and 8.4%
less molecules than levobupivacaine. Although molar differences between drugs are relatively
slight, a small reduction in molar concentration may provide similar pain relief, but result
in a large reduction in side effects due to the shape and position of the efficacy and side
effect dose response curves.
Comparative studies of all three drugs have been inconclusive. Intrathecal studies have
shown a potency hierarchy of bupivacaine > levobupivacaine > ropivacaine, but equivalent
potency between levobupivacaine and ropivacaine when injected with the opioid, sufentanil.
Epidural studies have also shown the potency of levobupivacaine to be equivalent or greater
than ropivacaine, but, when combined with sufentanil at "equipotent doses", both have shown
a longer duration of analgesia than bupivacaine.
Use of %w/v solutions, addition of opioids, pre-study assumptions of "equipotency" and
variable definitions of pain relief have all served to confuse the issue of local
anaesthetic potency and no definite conclusion exists as to whether any drug displays an
advantage when given by either the intrathecal or epidural route.
A second controversy concerns the mode of drug administration. Although epidural analgesia
is popular in Scotland for initiating pain relief in labour, major centres in the South of
England, Europe and North America use a combined technique of spinal followed by epidural
analgesia. The principal advantage is quicker pain relief, but the rapid onset of action may
be associated with hypotension, motor block and technical failure.
A need exists to define the best local anesthetic and technique for pain relief in early
labour. We suggest that calculating the molar Effective Dose for bupivacaine,
levobupivacaine and ropivacaine given both by the intrathecal and epidural routes would
provide a valid comparison between the pain relieving properties of all three drugs, from
which a reasoned assessment of side effects could be made.
Thus, our aim is to compare molar concentrations of bupivacaine, levobupivacaine and
ropivacaine when injected into the intrathecal and epidural spaces for pain relief in the
first stage of labour, allowing a rational, molar comparison of the intrathecal and epidural
efficacy of all three drugs, and thus providing a meaningful side effect profile. Only then
can an informed decision be made regarding best practice.
Study design Phase IV, single centre, randomised, single-blind study in pain relief during
early labor.
Primary objective To determine the median effective concentration of bupivacaine,
levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief
in the first stage of labor.
Secondary objectives To chart a derived dose response curve for bupivacaine, levobupivacaine
and ropivacaine after intrathecal and extradural injection Determine the intrathecal /
epidural potency ratio of each drug To measure the degree of motor block using Bromage and
Straight Leg Raising scales To measure side effects such as hypotension, nausea and vomiting
To measure mode of delivery and fetal outcome
Number and type of patients 162 patients requesting pain epidural relief in early labour
Recruitment and allocation All patients presenting to the ante natal clinic and not
scheduled for cesarean section will be approached for recruitment to this study. Patients
expressing an interest in participation will be given an information sheet and a written
consent form. Patients will be given at least 24 hours to make a decision about study
involvement. Allocation to six groups will be by computer randomised number generation.
Recruitment and allocation All patients presenting to the ante natal clinic and not
scheduled for cesarean section will be approached for recruitment to this study. Patients
expressing an interest in participation will be given an information sheet and a written
consent form. Patients will be given at least 24 hours to make a decision about study
involvement. Allocation to six groups will be by computer randomised number generation.
Inclusion criteria
- The patient is aged > 18 years
- The patient is in early labour ≤ 5cm cervical dilation
- The patient is American Association of Anaesthesiologists Grade I - II
- The patient provides written informed consent to participate in the trial prior to
surgery.
Exclusion criteria
- The patient has any known chronic medical condition for which regular medication is
required
- The patient has received any investigational drug within the 90 days prior to the study
or is scheduled to receive one during the study period.
- The patient is scheduled for caesarean section
- The patient has received opioids in the last 4 hours
- The patient has evidence of alcohol or drug abuse
- There is evidence of obstetric complications
- The fetus has shown signs of intrauterine growth retardation
- The patient has findings on pre-study evaluations (e.g. laboratory results, medical
history, physical examination, ECG) that are clinically significant in the
investigator's opinion such to exclude entry into the study.
Intervention
Following informed and written consent, patients will be randomised into six groups:
Patients, ward staff and primary investigator will be blinded to the study drug. Study drugs
will be prepared according to Hospital Department of Pharmacy guidelines on the preparation
of drugs for clinical studies. All study preparations will be coded with an equal chance of
receiving one of six infusions.
All patients will receive:
- Size 16g intravenous cannula
- Hartmann's solution 500ml infused at 100ml h-1
- Epidural analgesia or intrathecal analgesia in order to standardise the intervention
3ml intrathecal starting at a mass of 10 µmol bupivacaine, levobupivacaine or
ropivacaine by a combined spinal-epidural analgesia technique (groups A, B, C).
o 20 ml epidural starting at a mass of 50 µmol bupivacaine, levobupivacaine or
ropivacaine (groups D, E, F),
Intrathecal saline placebo will not be used because intrathecal injection influences
subsequent epidural spread and increases the risk of hypotension.
Assessments The primary pain assessment will be the 100mm Visual Analog Scale. The visual
analog will be performed pre-epidural, and at 5 minute intervals after epidural insertion
for 30 minutes, and every 5 minutes for a further 15 minutes in "unsuccessful" patients as
highlighted below.
Three responses to epidural analgesia will be charted.
1. Successful "Excellent"pain relief ≤ 10 mm at any time within 30 min of epidural
insertion
2. Unsuccessful "Good or reasonable" pain relief > 10mm at all times within 30 min of
epidural insertion, but ≤ 10 mm within 45min after rescue injection of 10ml 0.25%
bupivacaine
3. Technical failure > 10mm at all times within 30 min of epidural insertion, and still >
10 mm within 45min despite rescue injection of 10ml 0.25% bupivacaine
Three decisions will be made based on each response:
Response
1. "Excellent"pain relief. Next patient receives: 1 mmol less intrathecal or 5 mmol less
epidural local anaesthetic
2. "Good or reasonable" pain relief. Next patient receives: 1 mmol more intrathecal or 5
mmol more epidural local anaesthetic
3. Technical failure Next patient receives same mass of drug
Concomitant Medication Additional analgesia will be allowed only in accordance with this
protocol. The patient will be allowed to take her present analgesic medication up to 12
hours preoperatively. Opiate-containing medication (including codeine containing
combinations) will not be allowed less than 4 hours pre-study.
Statistical analysis Data analysis will proceed according to guidelines for randomised
controlled trials. The first stage of analysis will be to use descriptive statistics to
describe recruited individuals in relation to those eligible, and to investigate
comparability of the trial arms at baseline. The primary analysis will be an
intention-to-treat comparison between the two groups for both primary and secondary
outcomes. The primary outcome will be presented as Effective Dose with confidence intervals.
Categorical data will be presented as number and % of events.
Justification of sample size Two-way analysis with 6 groups. However the maximum number of
logical comparisons within an effect can be reduced to 6 such that the threshold P value for
significance at the P<0.05 level will be P=0.0085
The coefficient of variation from the isobole study is approximately 20%. The coefficient of
variation from the an intrathecal study ranged from about 15% to 18%.
So to detect a nominal 30% difference in potency, we will need N=27 per group for an up-down
design with 90% power.
Ethical Considerations:
This study will be conducted in accordance with the Declaration of Helsinki and the
Guidelines on Good Clinical Practice. The study will be submitted to a Multi-Centre Research
Ethics Committee followed by Local Research Ethics Committees for approval prior to
commencing the study.
Safety Evaluation:
Side effects or adverse events. Assessments of blood pressure, respiratory rate, nausea,
retching/vomiting and sedation at will occur at 5 minute intervals for the first 30 minutes
after insertion of the epidural catheter, then at 45 minutes if necessary. The incidence and
severity of nausea /vomiting/sedation will be assessed using a verbal rating score.
Serious Adverse Events will be defined as foetal or maternal haemodynamic or cerebral side
effects occurring within 15 minutes of epidural or spinal injection
- Foetal heart rate < 100 bpm
- Maternal hypotension < 30% pre-epidural level
- Bradycardia <50bpm
- Any cardiac arrythmia
- Convulsions
- Residual neurological damage
- Dizziness or headache
- Fever > 38 centigrade
All serious adverse events will be immediately reported to the Ethics committee and Medicine
and Health Regulatory Authority
