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NCT00780936 Clinical Trial

Effects of a Peripheral Nerve Block on Biomarkers of Pain and Inflammation

Pain Clinical Trial

Official title:
Effect of Peripheral Nerve Block on Inflammatory and Nociceptive Biomarkers in a UV-B Burn Model in Humans

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00780936
Other study ID # SU-01222008-984
Secondary ID eProtocol number
Status Completed
Phase N/A
First received October 24, 2008
Last updated November 21, 2008
Start date October 2007
Est. completion date July 2008

Study information
Verified date November 2008
Source Stanford University
Contact n/a
Is FDA regulated No
Health authority USA:Stanford University Panel on Human Subjects
Study type Interventional

Clinical Trial Summary

The purpose of this study is to determine the effect of a local anesthetic nerve block on markers of inflammation and pain after a sunburn. This is important because it may provide information regarding the way that nerve blocks help with the treatment of pain and in particular provide preemptive analgesia.

Recruitment information / eligibility
Status Completed
Enrollment 15
Est. completion date July 2008
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria:1. Between 18 and 50 years of age 2. Fluent in English language 3. Provide written informed consent 4. Skin pigmentation type II or III Exclusion Criteria:1. Current use of prescription drugs interfering with study objective 2. Use of over-the-counter analgesic/anti-inflammatory drugs within 48h of study participation 3. Current acute or chronic pain conditions 4. Significant medical conditions including psychiatric, neurological, and dermatological diseases 5. Pregnancy 6. Allergies to study drug(s) 7. Concomitant participation in other study protocol

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Related Conditions & MeSH terms

Intervention

Procedure:
• femoral nerve block

Locations
Country Name City State
United States Stanford University School of Medicine Stanford California

Sponsors (1)
Lead Sponsor Collaborator
Stanford University

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Measurement of the effect of a preemptive peripheral nerve block on the hyperalgesic response to an artificially induced sunburn.
Secondary Measurement of the effect of a preemptive peripheral nerve block on the release of pro-inflammatory cytokines.
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