The Effect of Intravenous Lidocaine on Allodynia

Pain Clinical Trial

Official title:

The Effect of Intravenous Lidocaine on Allodynia (Carl Koller Grant)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00659633
• Other study ID #: F061204014
• Status: Completed
• Phase: N/A
• First received: April 14, 2008
• Last updated: June 6, 2017
• Start date: December 2008
• Est. completion date: August 2016

Study information

• Verified date: June 2017
• Source: University of Alabama at Birmingham
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to study if lidocaine, given intravenously, reduces pain.

Description:

Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: August 2016
• Est. primary completion date: June 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years and older

Eligibility

Inclusion Criteria:

• Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi

Exclusion Criteria:

• History of Substance abuse

• Other Medications: CRPS patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis.

• Coronary Artery Disease (CAD): unstable

• Congestive Heart Failure (CHF): unstable

• Heart Arrhythmia: symptomatic

• Chronic Obstructive Pulmonary Disease (COPD)

• Lidocaine Allergy

• Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation.

• Presence of Contraindications for MRI

• Presence of electronically, magnetically, and mechanically activated implants

• Electronically, magnetically, and mechanically activated implants

• Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators

• Cardiac pacemakers

• Metallic splinters in the eye

• Ferromagnetic haemostatic clips in the central nervous system (CNS)

• Claustrophobia

• Pregnancy

Related Conditions & MeSH terms

• Hyperalgesia
• Pain

Intervention

Drug:
• lidocaine
intravenous, effect site concentration: 2mcg/ml, 15-20 min infusion, once

Locations

Country	Name	City	State
United States	University of Alabama at Birmingham	Birmingham	Alabama

Sponsors (2)

Lead Sponsor	Collaborator
University of Alabama at Birmingham	American Society of Regional Anesthesia

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pain Perception	Assessing heat pain perception (pain intensity) before, during, and after lidocaine infusion by means of patient self-report using a mechanical slide algometer.; The mechanical slide algometer [Price et al. (1994)] looks like a ruler that exposes a red bar with the end-points: no pain (left) and most pain imaginable (right). The use the slider to express their perceived pain. On the back of the ruler a numerical scale ranging from 0 top 10 translates the patient's rating into a numeric scale.	Participants will be followed from baseline through 128 minutes