Implication of Two Doses of O2-O3 Upon the Pain Alleviation in Patients With Low Back Pain

Pain, Chronic Clinical Trial

Official title: Implication of Two Different Doses of Intradiscal O2-O3 Injection Upon the Pain Alleviation in Patients With Low Back Pain: A Randomized, Single-blind Study

Status Completed

Clinical Trial Summary

Low back pain is very common problem, variable modalities have been introduced to control such problem. One of the emerging modalities is the ozone - oxygen (O2-O3 ) mixture that could reduce the herniation disk size and inflammation.

Clinical Trial Description

Intervertebral disc herniation is the most common problem which induces low back pain LBP. The number of patients seek surgical and or alternative therapy increases. The rate of re-operation is between 7-9% at 2 years and increases up to 10-25% at ten years postoperative.

Epidural injections with local anesthetics and steroids are one of the most commonly used interventions in managing chronic low back pain and lower extremity pain of various causes. However, despite their extensive use, debate continues on this medications effectiveness due to the lack of well-designed, randomized, controlled studies to determine the effectiveness of epidural injections in general, and caudal epidural injections in particular.

Ozone in mixture with oxygen has been justified in multiple studies have been done, this study aims to evaluate variable doses of this mix upon patient satisfaction, pain alleviation over 12 month follow up period . ;

Related Conditions & MeSH terms

• Back Pain
• Chronic Pain
• Low Back Pain
• Pain, Chronic

• NCT number: NCT03023969
• Study type: Interventional
• Source: Assiut University
• Status: Completed
• Phase: N/A
• Start date: August 2015
• Completion date: December 2016