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Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers

Healthy Clinical Trial

Official title:
Understanding Rebound Pain After Regional Anesthesia Resolution: Mechanistic Trial in Healthy Volunteers

Clinical Trial Summary

Regional anesthesia decreases postoperative pain scores and opioid consumption, and may prevent chronic pain after surgery in patients undergoing surgery. However, some patients experience an increase of pain into the severe range when the nerve block wears off, also known as rebound pain. The investigators are studying if a nerve block (numbing injection) in the arm causes hyperalgesia (increased pain) when the nerve block is wearing off.

Clinical Trial Description

This is a prospective, randomized study in healthy volunteers who will undergo sensory testing using quantitative sensory testing (QST), complete psychosocial and pain questionnaires, and ultrasound-guided peripheral nerve block of the arm (axillary nerve block) in a supervised, monitored setting (BWH Clinical Investigation Center). The investigators plan to assess the association between different QST modalities at different time points pre- and post-nerve block resolution. Semi-structured interviews and qualitative analysis will be used to explore patient's experiences with nerve block placement. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06005480
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Completed
Phase Phase 1
Start date September 28, 2023
Completion date May 28, 2024
View Details
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