Creatine and GAA for Brain Oxygenation

Oxygen Deficiency Clinical Trial

— CREGAA-OXY  

Official title:

Enhancing Brain Oxygenation: Effects of Short-Term Co-Administration of Creatine and Guanidinoacetic Acid at Rest and During Stress

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06371651
• Other study ID #: 23-1462-3
• Status: Completed
• Phase: N/A
• Start date: March 1, 2024
• Est. completion date: April 12, 2024

Study information

• Verified date: May 2024
• Source: University of Novi Sad, Faculty of Sport and Physical Education
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main aim of this randomized controlled trial is to evaluate cerebral blood oxygenation after 7-day administration of a creatine-guanidinoacetic acid (GAA) mixture in healthy adults before, during, and after a series of cognitive tests.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: April 12, 2024
• Est. primary completion date: April 10, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Age 18-30 years

• Absence of metabolic disorders or other health complications

• Provision of signed informed consent

Exclusion Criteria:

• History of dietary supplement use within the preceding 4 weeks

• Lack of consent to randomization

• Concurrent participation in other studies

Related Conditions & MeSH terms

• Hypoxia
• Oxygen Deficiency

Intervention

Dietary Supplement:
• Supplement
Dietary supplement containing creatine and guanidinoacetic acid
• Placebo
Inert substance

Locations

Country	Name	City	State
Serbia	Applied Bioenergetics Lab at Faculty of Sport and PE	Novi Sad	Vojvodina

Sponsors (1)

Lead Sponsor	Collaborator
University of Novi Sad, Faculty of Sport and Physical Education

Country where clinical trial is conducted

Serbia, 

References & Publications (2)

Hammett ST, Wall MB, Edwards TC, Smith AT. Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal. Neurosci Lett. 2010 Aug 2;479(3):201-5. doi: 10.1016/j.neulet.2010.05.054. Epub 2010 May 24. — View Citation

Watanabe A, Kato N, Kato T. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neurosci Res. 2002 Apr;42(4):279-85. doi: 10.1016/s0168-0102(02)00007-x. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain oxygen saturation	Percentage of oxygen saturation in prefrontal brain	Change from baseline brain oxygen saturation at 2 weeks
Secondary	Hemoglobin index	Concentration of hemoglobin index in prefrontal brain	Change from baseline hemoglobin index at 2 weeks

External Links

•   Web page of study lab