Clinical Trials Logo
  1. Home
  2. Oxygen Deficiency
  3. NCT06371651
  4. Details
NCT06371651 Clinical Trial

Creatine and GAA for Brain Oxygenation

Oxygen Deficiency Clinical Trial

— CREGAA-OXY  

Official title:
Enhancing Brain Oxygenation: Effects of Short-Term Co-Administration of Creatine and Guanidinoacetic Acid at Rest and During Stress

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06371651
Other study ID # 23-1462-3
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 1, 2024
Est. completion date April 12, 2024

Study information
Verified date May 2024
Source University of Novi Sad, Faculty of Sport and Physical Education
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The main aim of this randomized controlled trial is to evaluate cerebral blood oxygenation after 7-day administration of a creatine-guanidinoacetic acid (GAA) mixture in healthy adults before, during, and after a series of cognitive tests.

Recruitment information / eligibility
Status Completed
Enrollment 19
Est. completion date April 12, 2024
Est. primary completion date April 10, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 30 Years
Eligibility Inclusion Criteria: - Age 18-30 years - Absence of metabolic disorders or other health complications - Provision of signed informed consent Exclusion Criteria: - History of dietary supplement use within the preceding 4 weeks - Lack of consent to randomization - Concurrent participation in other studies

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Supplement
Dietary supplement containing creatine and guanidinoacetic acid
• Placebo
Inert substance

Locations
Country Name City State
Serbia Applied Bioenergetics Lab at Faculty of Sport and PE Novi Sad Vojvodina

Sponsors (1)
Lead Sponsor Collaborator
University of Novi Sad, Faculty of Sport and Physical Education

Country where clinical trial is conducted

Serbia, 

References & Publications (2)

Hammett ST, Wall MB, Edwards TC, Smith AT. Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal. Neurosci Lett. 2010 Aug 2;479(3):201-5. doi: 10.1016/j.neulet.2010.05.054. Epub 2010 May 24. — View Citation

Watanabe A, Kato N, Kato T. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neurosci Res. 2002 Apr;42(4):279-85. doi: 10.1016/s0168-0102(02)00007-x. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Brain oxygen saturation Percentage of oxygen saturation in prefrontal brain Change from baseline brain oxygen saturation at 2 weeks
Secondary Hemoglobin index Concentration of hemoglobin index in prefrontal brain Change from baseline hemoglobin index at 2 weeks
See also
  Status Clinical Trial Phase
Completed NCT04597983 - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists N/A
Recruiting NCT05858463 - High Intensity Interval Training and Muscle Adaptations During PR N/A
Completed NCT03331471 - Alveolar Recruitment Maneuver During Pneumoperitoneum N/A
Completed NCT04626453 - Oxygenation Changes After 2-month Exercise in Sedentary Older Adults With Diabetes N/A
Enrolling by invitation NCT04322994 - THRIVE Use in Pediatric Populations- Multi Site N/A
Not yet recruiting NCT05578131 - High-flow Nasal Cannula for Pediatric Anesthetic Induction N/A
Completed NCT05677009 - Sustainable Preservation of Essential Oxygen Resources: A Phase 4 Crossover Study of the BUFEO System: SAVE O2 N/A
Completed NCT04612270 - Quantification of Clinically Relevant Drug Induced Changes in HbO2 Affinity N/A
Completed NCT04584788 - Validation of the O3 Regional Somatic Tissue Oxygenation Monitor N/A
Recruiting NCT04141956 - Incidence of Use of High-Flow Nasal Cannula Oxygen Therapy in Intensive Care Units Patients
Completed NCT04973046 - Tissue Oxygen Saturation for Esophagectomy
Terminated NCT03665259 - Lower Inspiratory Oxygen Fraction for Preoxygenation N/A
Recruiting NCT03396172 - FreeDom: Innovative Strategy for the Management of COPD Exacerbations N/A
Completed NCT03128372 - Validation of Next Generation Cerebral and Tissue Oximeter N/A
Completed NCT05430724 - The Effects of Nicardipine and Esmolol Applied for Controlled Hypotension N/A
Recruiting NCT05783050 - Wei Nasal Jet Tube vs Nasal Cannula Oxygen Support in Gastrointestinal Endoscopy Patients N/A
Completed NCT04711317 - Pre-oxygenation With High-flow Nasal Cannula in Caesarian Section Under General Anesthesia N/A
Completed NCT03185507 - The Effect of Cryotherapy on Cerebral Hemodynamics Within Healthy Subjects Phase 1
Completed NCT04266665 - Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome Phase 4
Completed NCT05866289 - Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure

External Links