BFR in Overweight Sedentary Subjects

Overweight Clinical Trial

Official title:

Effects of a Physical Activity Program With Partial Vascular Occlusion on Body Composition, Biomechanics and Walking Energy in Overweight Sedentary Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05371119
• Other study ID #: 2021-02081
• Status: Completed
• Phase: N/A
• Start date: February 1, 2022
• Est. completion date: April 15, 2022

Study information

• Verified date: May 2022
• Source: University of Lausanne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This project should allow the investigators to observe the effects of low load training under partial vascular occlusion (BFR) in comparison with resistance training at low load without partial vascular occlusion in sedentary people overweight on parameters : decrease in fat mass; increase in muscle mass 79; muscle strength; decrease in the energy cost of walking; increase in preferred walking speed; improvement in walking pattern in patients overweight. Training under partial vascular occlusion should facilitate physical activity in overweight people as it can be just as effective as a "classic" type training with heavy loads. Thus, this device could allow people for who wear heavy loads can present an obstacle to physical activity to feel more involved in the physical activity programs offered in medical or sports centers.

Description:

The main objective of this study is to observe the effects of low load training under vascular occlusion (BFR) compared with low load resistance training without vascular occlusion in overweight sedentary people on parameters such as: decrease in fat mass; lower blood sugar levels as well as lower blood triglycerides and cholesterol levels; increased muscle mass; muscle strength; the reduction of the energy cost of walking; increasing the preferred walking speed; improving the walking pattern in overweight patients.

3.2 Primary and secondary endpoints

The first hypothesis is that the BFR drive will be effective in improving walking economy (thus reducing the energy cost of walking) and increasing the preferred walking speed, by improving walking patterns.

The second hypothesis is that BFR training makes it possible to modify the body composition in a slight way and to promote the gain of muscle strength in overweight individuals who do not practice physical activity beforehand. In addition, blood tests will show a decrease in blood sugar, blood triglyceride levels and cholesterol.

3.3 Study design

This single-center project aims to test the effects of low-load training under partial vascular occlusion (BFR) compared to low-load resistance training without vascular occlusion in overweight sedentary people. The main expected effects are a decrease in fat mass, an increase in muscle mass and strength, a decrease in the energy cost of walking as well as an increase in preferential walking speed. This project is part of a continuity of research in a public health context in order to propose adapted and effective physical activity programs for an overweight population unable to train with heavy loads.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: April 15, 2022
• Est. primary completion date: April 15, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

• IMC between 25 and 35

• vaccin against Covid-19

Exclusion Criteria:

hypertension diabete

Related Conditions & MeSH terms

• Overweight

Intervention

Other:
• Exercise Intervention
Training with light load with blood flow restriction (BFR)

Locations

Country	Name	City	State
Switzerland	ISSUL	Lausanne	VD

Sponsors (1)

Lead Sponsor	Collaborator
University of Lausanne

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	DEXA technology	Body composition assessment: relative lean and fat mass in all body segments	One week before intervention
Primary	DEXA technology	Body composition assessment: relative lean and fat mass in all body segments	One week following the training intervention
Primary	Evaluation of muscle strength from an isokinetic device	eccentric and concentric peak torque of the knee extensor muscles	One week before intervention
Primary	Evaluation of muscle strength from an isokinetic device	eccentric and concentric peak torque of the knee extensor muscles	One week following the training intervention
Primary	Evaluation of the preferential speed of walking in an ecological situation	using of a treadmill with measurement of the ground reaction forces	One week before interventionn
Primary	Evaluation of the preferential speed of walking in an ecological situation	using of a treadmill with measurement of the ground reaction forces	One week following the training intervention
Primary	Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.	calculation of the mechanical work	One week before intervention
Primary	Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.	calculation of the mechanical work	One week following the training intervention
Primary	Evaluation of the energy cost of walking	on a treadmill, by indirect calorimetry with gaz exchanges	One week before intervention
Primary	Evaluation of the energy cost of walking	on a treadmill, by indirect calorimetry with gaz exchanges	One week following the training intervention