Effects of Dietary Protein on Undesirable Postprandial Events in Overweight Subjects

Overweight Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00931151
• Other study ID #: SURPROL 2
• Status: Completed
• Phase: N/A
• First received: July 1, 2009
• Last updated: August 22, 2011
• Start date: April 2009
• Est. completion date: July 2009

Study information

• Verified date: March 2010
• Source: Institut National de la Recherche Agronomique
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Direction Générale de la Santé
• Study type: Interventional

Clinical Trial Summary

Dietary protein differing by their amino acid composition could modulate undesirable metabolic and functional responses to a meal rich in saturated fat and sugars. This study aims at examining the specific effects of dairy protein with different cysteine contents on the postprandial undesirables effects elicited by the ingestion of a high fat meal in overweight subjects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: July 2009
• Est. primary completion date: July 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• BMI between 25 and 30

• Waist circumference > 94 cm

Exclusion Criteria:

• Allergy to milk protein

• Abusive drug consumption

• Smoking

• Hypertension, diabetes

• High level of physical activity

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Overweight

Intervention

Dietary Supplement:
• Postprandial metabolic and functional measures
After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.

Locations

Country	Name	City	State
France	Centre de recherche sur volontaires	Bobigny

Sponsors (2)

Lead Sponsor	Collaborator
Institut National de la Recherche Agronomique	National Research Agency, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Endothelial dysfunction		0-2-4-6 hours (after meal ingestion)	No
Secondary	Postprandial inflammation		0-0.5-1-1.5-2-3-4-6 hours (after meal ingestion)	No