Exercise-snacks at Work: Impact on Cardiometabolic Parameters

Overweight and Obesity Clinical Trial

Official title:

Exercise-snacks: an Effective Strategy to Break Sitting Time and Improve Cardiometbaolic Health in Sedentary Overweight Office Workers

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05942144
• Other study ID #: AU-062023-AVJ
• Status: Recruiting
• Phase: N/A
• Start date: May 16, 2023
• Est. completion date: July 20, 2024

Study information

• Verified date: July 2023
• Source: University of Avignon
• Contact: Agnès VINET
• Phone: +33413951344
• Email: agnes.vinet[@]univ-avignon.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health

Description:

Backgrounds: Very short (< 1 minute) and intense exercises, entitled "exercise-snacks", have been reported to be effective 1) in improving physical fitness over 6 weeks and 2) in improving vascular function and lowering blood glucose levels over one day. These studies were all carried out in the laboratory. The question therefore arises as to whether these acute vascular and metabolic benefits, as well as those on physical fitness, are sustainable over time following a chronic "exercise-snacks" program applicable in the professional environment to sedentary, overweight people. Aims of this project is therefore to measure the effects of an "exercise-snacks" type physical activity program in the workplace of administrative staff on the cardio-metabolic health and sedentary behaviour of staff.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: July 20, 2024
• Est. primary completion date: June 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 60 Years

Eligibility

Inclusion Criteria:

• administrative staff,
• age between 30 and 60,
• body mass index =25kg/m²,
• sedentary time =7h/day,
• minimum 3 working days on site,
• no known cardiovascular or metabolic pathology, social security affiliation or benefit,
• ability and willingness to give free, written and informed consent.

Exclusion Criteria:

• pregnant or breast-feeding women,
• anti-hypertensive treatment, beta-blockers and anti-diabetics,
• known contraindications to physical activity (articular, cardiac or other),
• exercise-induced asthma,
• lack of motivation of subjects posing problems of compliance and adherence to the exercise program,
• participation in a study in the preceding 3 months, ongoing participation in a clinical trial.

Related Conditions & MeSH terms

• Overweight
• Overweight and Obesity
• Sedentary Time
• Work-Related Condition

Intervention

Other:
• Exercise-snacks program
Subjects in the exercise-snacks group will perform 4 "exercise-snacks" sessions per working day for 4 weeks. These sessions will consist of 80 one-to-one walks to be completed as quickly as possible. They will also receive information about their attitudes to physical activity.

Locations

Country	Name	City	State
France	Avignon University	Avignon

Sponsors (1)

Lead Sponsor	Collaborator
University of Avignon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in aerobic fitness	Aerobic fitness will be assessed via the Chester step test's prediction of VO2max	at inclusion, at the end of the 4-weeks program and 1 month following the end of the program
Secondary	Adherence of staff in the experimental group by analyzing accelerometric data.	Total number of exercise-snacks performed during the 4-week program by analysing accelerometers data	during the 4-weeks program
Secondary	Intensity of exercise-snacks	Heart rate during exercise-snacks in % heart rate max	during the 4-weeks program
Secondary	Changes in flow mediated dilation of superficial femoral artery	measured by echocardiography (Vivid Q, GE) , in %	at inclusion, at the end of the 4-weeks program
Secondary	Changes in peak shear rate of superficial femoral artery	measured by echocardiography (Vivid Q, GE) during hyperemia, in s-1	at inclusion, at the end of the 4-weeks program
Secondary	Changes in nitrate mediated dilation of superficial femoral artery	by echocardiography (Vivid Q, GE), in %	at inclusion, at the end of the 4-weeks program
Secondary	Changes in superficial femoral artery compliance	by echocardiography (Vivid Q, GE), in mm2 mmHg-1	at inclusion, at the end of the 4-weeks program
Secondary	Changes in carotid intima-thickness	by echocardiography (Vivid Q) in mm	at inclusion, at the end of the 4-weeks program
Secondary	Changes in carotid compliance	by echocardiography (Vivid Q) in mm2 mmHg-1	at inclusion, at the end of the 4-weeks program
Secondary	Changes in carotid-femoral pulse wave velocity	by Sphygmocor, in m.s-1	at inclusion, at the end of the 4-weeks program
Secondary	Changes in post-occlusive skin perfusion	by Laser Doppler (Perimed), in perfusion unit, in area under the curve, in time to peak	at inclusion, at the end of the 4-weeks program
Secondary	Changes in blood pressure	systolic, diastolic, mean and pulsed	at inclusion, at the end of the 4-weeks program and 1 month following the end of the program
Secondary	Changes in mean amplitude of glycemic excursions	measured by continuous glucose monitoring (FreeStyle), in mmol.L-1	one week before the beginning of the program and the first week of the program and the 2 lastest weeks of the program
Secondary	Changes in heart rate	Heart rate at rest, at the end of the Chester step test and during exercise	between the beginning and end of the 4-week exercise program and 4 weeks after the program.
Secondary	Changes in level of habitual physical activity	Physical Activity questionnaire	between the start and end of the 4-week exercise program and 4 weeks after the program
Secondary	Changes in fat mass	measured by InBody, in kg	between the start and end of the 4-week exercise program and 4 weeks after the program
Secondary	Changes in lean mass	measured by InBody, in kg	between the start and end of the 4-week exercise program and 4 weeks after the program
Secondary	Change in physical activity behaviour at work of staff	Theory of planned behavior questionnaire, score range from 20 to 80 with higher scores mean a better outcome.	between the start and end of the 4-week exercise program.
Secondary	Changes in rating of perceived exertion	measured during the Chester test, score range from 7 to 20 with higher scores mean a worse outcome.	between the start and end of the 4-week exercise program and 4 weeks after the program