Overweight and Obesity Clinical Trial
Official title:
Exercise-snacks: an Effective Strategy to Break Sitting Time and Improve Cardiometbaolic Health in Sedentary Overweight Office Workers
The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health
Status | Recruiting |
Enrollment | 40 |
Est. completion date | July 20, 2024 |
Est. primary completion date | June 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 30 Years to 60 Years |
Eligibility | Inclusion Criteria: - administrative staff, - age between 30 and 60, - body mass index =25kg/m², - sedentary time =7h/day, - minimum 3 working days on site, - no known cardiovascular or metabolic pathology, social security affiliation or benefit, - ability and willingness to give free, written and informed consent. Exclusion Criteria: - pregnant or breast-feeding women, - anti-hypertensive treatment, beta-blockers and anti-diabetics, - known contraindications to physical activity (articular, cardiac or other), - exercise-induced asthma, - lack of motivation of subjects posing problems of compliance and adherence to the exercise program, - participation in a study in the preceding 3 months, ongoing participation in a clinical trial. |
Country | Name | City | State |
---|---|---|---|
France | Avignon University | Avignon |
Lead Sponsor | Collaborator |
---|---|
University of Avignon |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in aerobic fitness | Aerobic fitness will be assessed via the Chester step test's prediction of VO2max | at inclusion, at the end of the 4-weeks program and 1 month following the end of the program | |
Secondary | Adherence of staff in the experimental group by analyzing accelerometric data. | Total number of exercise-snacks performed during the 4-week program by analysing accelerometers data | during the 4-weeks program | |
Secondary | Intensity of exercise-snacks | Heart rate during exercise-snacks in % heart rate max | during the 4-weeks program | |
Secondary | Changes in flow mediated dilation of superficial femoral artery | measured by echocardiography (Vivid Q, GE) , in % | at inclusion, at the end of the 4-weeks program | |
Secondary | Changes in peak shear rate of superficial femoral artery | measured by echocardiography (Vivid Q, GE) during hyperemia, in s-1 | at inclusion, at the end of the 4-weeks program | |
Secondary | Changes in nitrate mediated dilation of superficial femoral artery | by echocardiography (Vivid Q, GE), in % | at inclusion, at the end of the 4-weeks program | |
Secondary | Changes in superficial femoral artery compliance | by echocardiography (Vivid Q, GE), in mm2 mmHg-1 | at inclusion, at the end of the 4-weeks program | |
Secondary | Changes in carotid intima-thickness | by echocardiography (Vivid Q) in mm | at inclusion, at the end of the 4-weeks program | |
Secondary | Changes in carotid compliance | by echocardiography (Vivid Q) in mm2 mmHg-1 | at inclusion, at the end of the 4-weeks program | |
Secondary | Changes in carotid-femoral pulse wave velocity | by Sphygmocor, in m.s-1 | at inclusion, at the end of the 4-weeks program | |
Secondary | Changes in post-occlusive skin perfusion | by Laser Doppler (Perimed), in perfusion unit, in area under the curve, in time to peak | at inclusion, at the end of the 4-weeks program | |
Secondary | Changes in blood pressure | systolic, diastolic, mean and pulsed | at inclusion, at the end of the 4-weeks program and 1 month following the end of the program | |
Secondary | Changes in mean amplitude of glycemic excursions | measured by continuous glucose monitoring (FreeStyle), in mmol.L-1 | one week before the beginning of the program and the first week of the program and the 2 lastest weeks of the program | |
Secondary | Changes in heart rate | Heart rate at rest, at the end of the Chester step test and during exercise | between the beginning and end of the 4-week exercise program and 4 weeks after the program. | |
Secondary | Changes in level of habitual physical activity | Physical Activity questionnaire | between the start and end of the 4-week exercise program and 4 weeks after the program | |
Secondary | Changes in fat mass | measured by InBody, in kg | between the start and end of the 4-week exercise program and 4 weeks after the program | |
Secondary | Changes in lean mass | measured by InBody, in kg | between the start and end of the 4-week exercise program and 4 weeks after the program | |
Secondary | Change in physical activity behaviour at work of staff | Theory of planned behavior questionnaire, score range from 20 to 80 with higher scores mean a better outcome. | between the start and end of the 4-week exercise program. | |
Secondary | Changes in rating of perceived exertion | measured during the Chester test, score range from 7 to 20 with higher scores mean a worse outcome. | between the start and end of the 4-week exercise program and 4 weeks after the program |
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