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Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL) — DISTAL  

Insulin Resistance Clinical Trial

Official title:
Using a Complex Carbohydrate Mixture Added to a High-protein Diet to Steer Fermentation and Improve Metabolic, Gut and Brain Health

Clinical Trial Summary

The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.

Clinical Trial Description

The fibre mixture that will be investigated is hypothesized to improved metabolic, gut and brain health. It potentially increases insulin sensitivity, satiety, gut barrier function, improves food-reward related brain activity and decreases inflammation, gut permeability, and ectopic lipid accumulation, among other potential health effects. The fibre mixture will be administrated during 12 weeks combined a high-protein diet. The placebo-controlled parallel design of the study allows for a placebo group to use maltodextrin combined with a high-protein diet for 12 weeks. The high-protein diet is known to increase satiety and might enhance the difference between the intervention and placebo groups in terms of outcome measurements. The potential health effects as described earlier will be investigated using different techniques. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05354245
Study type Interventional
Source Maastricht University Medical Center
Contact Colin AJ van Kalkeren, M.D.
Phone +31 (0)43 3881638
Email c.vankalkeren@maastrichtuniversity.nl
Status Recruiting
Phase N/A
Start date September 8, 2022
Completion date December 2024
View Details
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