Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

Overweight and Obesity Clinical Trial

Official title:

Longitudinal Interaction Between APOA5 -1131T>C and Overweight

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03367598
• Other study ID #: PA_fu_APOA5_rs662799
• Status: Completed
• Phase: N/A
• First received: December 4, 2017
• Last updated: December 4, 2017
• Start date: January 1, 2008
• Est. completion date: December 31, 2013

Study information

• Verified date: December 2017
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 503
• Est. completion date: December 31, 2013
• Est. primary completion date: December 1, 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 65 Years

Eligibility

Inclusion Criteria:

• Nondiabetic (fasting serum glucose concentration < 126 mg/dL)

• Nonobese (BMI = 25 kg/m2)

Exclusion Criteria:

• Current and/or past history of cardiovascular disease

• Diabetes mellitus (fasting glucose levels =126 mg/dL)

• Abnormal liver or renal function

• Thyroid or pituitary disease

• Pregnancy or lactation

• Regular use of any medication

Related Conditions & MeSH terms

• Overweight
• Overweight and Obesity

Intervention

Genetic:
• rs662799 (APOA5 -1131T>C)
Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brachial-ankle PWV (baPWV)	cm/s	at baseline
Primary	Brachial-ankle PWV (baPWV)	cm/s	3-year follow-up
Secondary	Triglyceride	mg/dL	at baseline
Secondary	Triglyceride	mg/dL	3-year follow-up