Walnuts to Achieve Lasting NUTrition to Prevent Diabetes

Status Completed

Clinical Trial Summary

Prediabetes is a precursor of type 2 diabetes and an independent risk factor for cardiovascular disease, and currently affects one-quarter of the population of the United States. Individuals of overweight or obese BMI are at particular high risk for incident diabetes. A major modifiable risk factor for type 2 diabetes is poor dietary quality, and improvement of dietary quality can effectively delay and even prevent type 2 diabetes. Interventions to improve dietary quality thus far, however, rely on short-term intensive clinically designed meals replacing the entire diet which have poor sustainability. Persistent improvements to daily dietary patterns are often difficult without directed guidance, and overall dietary quality in the United States remains poor. The identification of a practical, daily dietary intervention to improve dietary quality and prevent diabetes in those at high risk remains unknown. The investigators propose to enroll 40 individuals with diagnosed prediabetes into a randomized controlled pilot study and provide a daily walnut supplementation intervention to determine feasibility and acceptability of the supplement. The investigators will then determine preliminary efficacy on metabolic markers and will investigate associations between dietary quality and circulating levels of branched-chain amino acids. The goal is to implement a whole-food supplement to improve dietary quality in patients with prediabetes as a tool for future type 2 diabetes prevention.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03334175
Study type	Interventional
Source	University of California, San Francisco
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	May 21, 2018
Completion date	August 5, 2019

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT03994419` - PErioperAtive CHildhood ObesitY
Recruiting	`NCT05354245` - Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)	N/A
Completed	`NCT03602001` - Attentive Eating for Weight Loss	N/A
Recruiting	`NCT06269159` - The Power of 24-hour: Co-designing Intervention Components
Completed	`NCT03377244` - Healthy Body Healthy Souls in the Marshallese Population	N/A
Completed	`NCT02996864` - Location-based Smartphone Technology to Guide College Students Healthy Choices Ph II	N/A
Completed	`NCT04647149` - Effects of Early and Delayed Time-restricted Eating in Adults With Overweight and Obesity	N/A
Terminated	`NCT03914066` - A Group-based Treatment of Overweight and Obesity in Primary Care	N/A
Completed	`NCT03685656` - Effect of ANACA3 Slimming Gel on Loss of Abdominal and Thigh Circumferences in Healthy Volunteers	N/A
Completed	`NCT05051579` - A Study of LY3502970 in Participants With Obesity or Overweight With Weight-related Comorbidities	Phase 2
Completed	`NCT04611477` - Effect of Synbiotic 365 on Body Composition in Overweight and Obese Individuals	N/A
Active, not recruiting	`NCT05330247` - Cut Down on Carbohydrate in the Dietary Therapy of Type 2 Diabetes - The Meal Box Study	N/A
Completed	`NCT03599115` - Effects of Inhibitory Control Training in Eating Behaviors	N/A
Recruiting	`NCT05938894` - Train Your Brain - Executive Function	N/A
Recruiting	`NCT06094231` - Treating Patients With Renal Impairment and Altered Glucose MetAbolism With TherapeutIc Carbohydrate Restriction and Sglt2-Inhibiton - a Pilot Study	N/A
Recruiting	`NCT05987306` - A Self-compassion Focused Intervention for Internalized Weight Bias and Weight Loss	N/A
Completed	`NCT03792685` - Looking for Personalized Nutrition for Obesity/Type 2 Diabetes Mellitus Prevention	N/A
Completed	`NCT05055362` - Effect a Honey, Spice-blended Baked Good Has on Salivary Inflammation Markers in Adults: a Pilot Study	N/A
Completed	`NCT04520256` - Rapid Evaluation of Innovative Intervention Components to Maximize the Health Benefits of Behavioral Obesity Treatment Delivered Online: An Application of Multiphase Optimization Strategy	Phase 2/Phase 3
Completed	`NCT04979234` - A Single Centre, Prospective Feasibility Study to Evaluate the Efficacy of an Endoluminal-suturing Device (Endomina) on Severe Obstructive Sleep Apnea Syndrome	N/A