The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors

Overweight and Obesity Clinical Trial

— BPS2  

Official title:

The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02951624
• Other study ID #: 53476
• Status: Completed
• Phase: N/A
• Start date: November 2016
• Est. completion date: July 15, 2018

Study information

• Verified date: December 2018
• Source: Rigshospitalet, Denmark
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.

Description:

Fifteen (n=15) sedentary adult overweight males will be included in the study. All participants will undergo the four interventions in a randomized cross-over design. Wash out between intervention will be minimum four days.

Control (CON): Participants will be sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.), with a target MET below 1.5 (i.e. 1.5 times REE). Participants will only be allowed to stand or walk to go to the toilet.

Breaker: Participants will be breaking up prolonged sitting with 2 min intervals of low intensity walking.

Intermediate: Participants will be breaking up prolonged sitting with 6 min intervals of low intensity walking

Prolonger: Participants will be breaking up prolonged sitting with 12 min intervals of low intensity walking

All interventions will be matched for total physical activity as well as sitting. Thus, we aim for the active interventions to be iso-caloric.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: July 15, 2018
• Est. primary completion date: July 15, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 50 Years

Eligibility

Inclusion Criteria:

• Males, age 20-50 years, waist-to-height ratio = 0.5 and/or waist circumference = 102 cm.

Exclusion Criteria:

• Clinically diagnosed diabetes, uncontrolled hypertension, use of glucose- and/or lipid-lowering medication, smoking, evidence of thyroid, liver, lung, heart or kidney disease, non-sedentary occupation, and VO2max levels above the considered average fitness according to age (Shvartz & Reibold 1990), contraindications to increased levels of physical activity.

Related Conditions & MeSH terms

• Metabolic Disease
• Metabolic Diseases
• Overweight
• Overweight and Obesity
• Sedentary Lifestyle

Intervention

Behavioral:
• Control
Control intervention
• Breaker
Short breaks of physical activity
• Prolonger
longer breaks of physical activity
• Intermediate
Intermediate breaks of physical activity

Locations

Country	Name	City	State
Denmark	Center for Physical Activity Research, Copenhagen University Hospital	Copenhagen

Sponsors (1)

Lead Sponsor	Collaborator
Rigshospitalet, Denmark

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	AUC post prandial glucose concentration		6 hours
Secondary	AUC post prandial insulin concentration		6 hours
Secondary	AUC post prandial c-peptide concentration		6 hours
Secondary	AUC post prandial triglyceride concentration		6 hours
Secondary	AUC post prandial total cholesterol concentration		6 hours
Secondary	AUC post prandial ldl concentration		6 hours
Secondary	AUC post prandial hdl concentration		6 hours
Secondary	AUC post prandial glucagon concentration		6 hours
Secondary	Mean 24 hour glucose concentration		24 hours
Secondary	Variation in 24 hour glucose concentration		24 hours
Secondary	Maximum in 24 hour glucose concentration		24 hours