Overweight and Obesity Clinical Trial
Official title:
Oxytocin Effects on Food Motivation Pathways
Verified date | April 2019 |
Source | Massachusetts General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Oxytocin is a peptide hormone produced in the brain that regulates food intake. However, the
mechanisms for this effect in humans is not yet clear.
In this study, the investigators will therefore examine the effect of a single dose of
intranasal oxytocin (compared to placebo) on levels of appetite-regulating hormones and
functional magnetic resonance imaging activation of areas of the brain involved in food
motivation.
Status | Completed |
Enrollment | 10 |
Est. completion date | May 2015 |
Est. primary completion date | May 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - Age 18-45 years old - BMI 25-40 - Regular breakfast eater (at least 4 times per week) - Stable weight within the past three months Exclusion Criteria: - Psychiatric disease, use of psychotropic medications - History of eating disorder - History of excessive exercise within the last three months (having run more that 25 miles in any one week or having exercised more than ten hours in any one week) - History of diabetes mellitus - Active substance abuse - Hematocrit lower than the normal range - Gastrointestinal tract surgery (including gastrectomy, gastric bypass surgery, and small or large bowel resection) - History of cardiovascular disease (such as hypertrophic cardiomyopathy, valvular heart disease, coronary heart disease, or coronary artery spasms) - Untreated thyroid disease - Tobacco use - Cardiac pacemaker, surgical aneurysm clips, neurostimulator, implanted pumps, metal fragments in body/eyes, nitroglycerin patch, severe claustrophobia |
Country | Name | City | State |
---|---|---|---|
United States | Massachusetts General Hospital | Boston | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in functional magnetic resonance imaging activation of food motivation brain regions | Functional magnetic resonance imaging at T60 min after oxytocin/placebo | ||
Secondary | Change in hormone levels (cholecystokinin, glucagon-like peptide-1) | Blood draws at T0, T30, T60, T120 min after oxytocin/placebo |
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