Overweight and Obesity Clinical Trial
Official title:
Obesity, Pain and Fertility: is There Any Association?
The overall aim of the study is to investigate if patients with musculoskeletal chronic pain have reduced semen quality in comparison with age matched healthy controls. Secondly, the aim is to investigate whether overweight with or without chronic pain are related to reduced semen quality. We will investigate semen quality in obese chronic pain patients, normal weight chronic pain patients and in obese and normal weight healthy controls.
Obesity is associated with several disorders including chronic musculoskeletal pain. For
example obesity has been implicated in the development or progression of low back pain and
knee osteoarthritis. The mechanism by which obesity causes lumbar back pain is poorly
understood, but the contribution of both mechanical and system factors is likely. Direct
mechanical stress on the intervertebral discs and adjacent structures are suspected to be
mechanisms through which obesity affects the spine, leading to subsequent low back pain. The
link between obesity and knee osteoarthritis has also been demonstrated, but potential
factors underlying the association of obesity with knee osteoarthritis has not entirely been
elucidated.
It is a well-known fact that obesity leads to an excess load on the joint, increased
cartilage turnover, increased collagen type 2 degradation products and increased risk of
degenerative meniscal lesions. Although all of these factors have been proposed to lead to
knee osteoarthritis, no causal relationship has been demonstrated.
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Observational Model: Case Control, Time Perspective: Retrospective
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