Clinical Trials Logo
  1. Home
  2. Overlap Syndrome
  3. NCT05190458

Evaluation of High Velocity Nasal Insufflation in Management of Respiratory Failure in Patients With Overlap Syndrome — HVNI  

Obesity Hypoventilation Syndrome Clinical Trial

Official title:
Evaluation of High Velocity Nasal Insufflation in Management of Respiratory Failure in Patients With Overlap Syndrome.

Clinical Trial Summary

High velocity nasal insufflation (HVNI), a form of HFNC that utilizes a small bore nasal cannula to generate higher velocities of gas delivery than HFNC which uses large bore cannula, has the ability to accomplish complete purge of extra thoracic dead space at flow rates of 35 litres/min and may be able to provide ventilatory support in patients with respiratory failure in addition to oxygenation support in patients with overlap syndrome. This study aims to evaluate the effectiveness of HVNI compared to NIMV in management of respiratory failure in patients with obesity hypoventilation syndrome and overlap syndrome.

Clinical Trial Description

Overlap syndrome (OVS) is the concurrence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), and is associated with poor outcomes. COPD and obstructive sleep apnoea (OSA) are highly prevalent and different clinical COPD phenotypes that influence the likelihood of comorbid OSA. The increased lung volumes and low body mass index (BMI) associated with the predominant emphysema phenotype protects against OSA whereas the peripheral oedema and higher BMI often associated with the predominant chronic bronchitis phenotype promote OSA. The diagnosis of OSA in COPD patients requires clinical awareness and screening questionnaires which may help identify patients for overnight study. Management of OSA-COPD overlap patients differs from COPD alone and the survival of overlap patients treated with nocturnal positive airway pressure is superior to those untreated. high flow nasal cannula (HFNC), which delivers heated, humidified oxygen via a nasal cannula at high flow rates of up to 60 L/min, delivering a maximum of 100% oxygen, has been shown to be effective in the treatment of respiratory failure. High velocity nasal insufflation (HVNI), a form of HFNC that utilizes a small bore nasal cannula to generate higher velocities of gas delivery than HFNC which uses large bore cannula, has the ability to accomplish complete purge of extra thoracic dead space at flow rates of 35 litres/min and may be able to provide ventilatory support in patients with respiratory failure in addition to oxygenation support in patients with obesity hypoventilation syndrome and overlap syndrome. This study aims to evaluate the effectiveness of HVNI compared to NIMV in management of respiratory failure in patients with overlap syndrome. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05190458
Study type Interventional
Source Assiut University
Contact Abanoub H Sadek Farag, Resident
Phone +201279269591
Email Abanoubabanoubhanysadek@outlook.com
Status Not yet recruiting
Phase N/A
Start date March 2023
Completion date June 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT01903135 - Prevalence of Obesity Hypoventilation Syndrome N/A
Recruiting NCT04098094 - Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Withdrawn NCT03861468 - Medico-economics and QoL of Obese Patients Followed by Medical Analysis Laboratories (BIOSAOS ) N/A
Completed NCT01368614 - AVAPS-AE Efficacy Study N/A
Terminated NCT01964339 - Obesity Hypoventilation Syndrome Prevalence Study
Completed NCT04108819 - Ketogenic Diet for Obesity Hypoventilation Syndrome N/A
Completed NCT02934581 - Prevalence Rate, and Clinical Characteristics of Obesity Hypoventilation Syndrome Via Screening Patients Admitted to Medical Intensive Care Units
Terminated NCT03353064 - Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure N/A
Completed NCT03085537 - Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis Platform
Recruiting NCT02980770 - Postoperative Complications in Patients With Obesity Hypoventilation Syndrome N/A
Completed NCT01499485 - Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation. Phase 3
Completed NCT01483716 - A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS) N/A
Completed NCT03506906 - The Debated Role of Sleep Studies in Patients Under Established Home Mechanical Ventilation N/A
Terminated NCT02317042 - Juno Perth Clinical Trial N/A
Withdrawn NCT01104610 - Target Volume Mode Controlled Ventilator in Obesity Hypoventilation Syndrome N/A
Completed NCT01405976 - Alternative of Treatment in Obesity Hypoventilation Syndrome N/A
Recruiting NCT03854058 - Respiratory Muscle Strength in Patients With Obesity Hypoventilation Syndrome (OHS) or With a Precursor of the Disease
Recruiting NCT04100616 - A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obesity
Completed NCT02342899 - Cost Effectiveness of Outpatient Set-up of Automated NIV in Obese Patients With Chronic Respiratory Failure Phase 3
Completed NCT01757444 - Non Invasive Ventilation : Efficacy of a New Ventilatory Mode in Patients With OHS N/A