Infertility Clinical Trial
Official title:
Efficacy of Dehydroepiandrosterone to Overcome the Effect of Ovarian Aging - A Pilot Double Blinded Randomised Controlled Trial
- To test the hypothesis that supplementation of DHEA for at least twelve weeks prior to
and during ovarian stimulation increases oocyte quantity (number of oocytes retrieved)
and oocyte quality (clinical pregnancy rates and molecular markers) following IVF and
IVF/ICSI treatment.
- To evaluate the feasibility of conducting a large multicentre trial
The purpose of this study is to evaluate the role of DHEA in counteracting the effects of
ovarian ageing in an in-vitro fertilization (IVF) model. The study will examine whether the
use of DHEA could improve clinical pregnancy rates following IVF treatment in women
predicted to have aged ovaries by increasing oocyte quantity (ovarian response to
gonadotrophins) and/ or by improving oocyte quality. The oocyte quality will be assessed by
morphological and molecular markers.
This study will provide a mechanistic framework for translational research on mechanisms of
ovarian ageing and drug interventions to slow down the ovarian ageing process and subsequent
adverse physical and psychological consequences. Further, the data that will be produced
from this research will have the potential to influence clinical practice in fertility
clinics worldwide.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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