| Eligibility |
Inclusion Criteria:
1. Female patient is at least 18 years of age,
2. Patient has signed the Informed Consent (ICF) and is able to comply with protocol
requirements.
3. Patient with histologically proven confirmed recurrent or persistent clear cell
carcinoma of the ovary, endometrium, cervix, vagina, and vulva
- Local review by gynecologic pathologist required
- =50% clear cell histology in case of mixed carcinoma
- WT-1 neg (Only in case of ovarian cancer) Note: In the case of including
non-ovarian clear cell carcinoma with more than 20 cases, the decision is made
through discussion with the SPONSOR.
4. Patient with an Eastern Cooperative Oncology Group (ECOG) performance status score of
0 or 1.
5. Disease progression within 12 months of completing platinum-based chemotherapy
6. 1-5 prior lines of therapies
7. Patient with measurable disease according RECIST 1.1 criteria
8. Availability of Tumor tissue for translational research . - A formalin-fixed
paraffin-embedded (FFPE) tumor block(preferred) or at least 20 slides (unstained,
freshly cut, serial sections) must be submitted.
9. Patients who consent to fresh tumor biopsies
- Confirmed with at least one lesion with location accessible to safely biopsy per
the clinical judgement of the investigator
- Note: If mandatory biopsies cannot be performed as per investigator's clinical
judgement, discussion and agreement between investigator and Sponsor are
required.
10. Patient has adequate organ function, defined as follows:
1. Absolute neutrophil count = 1,500 cells/µL
2. Platelets = 100,000 cells/µL
3. Hemoglobin = 9 g/dL or = 5.6 mmol/L
4. Serum creatinine = 1.5× upper limit of normal (ULN) or calculated creatinine
clearance = 50 mL/min using the Cockcroft-Gault equation for patients with
creatinine levels > 1.5× institutional ULN
5. Total bilirubin = 1.5× ULN (= 2.0 x ULN in patients with known Gilbert's
syndrome) or direct bilirubin = 1× ULN
6. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) = 2.5× ULN
unless liver metastases are present, in which case they must be = 5× ULN
7. International normalized ratio or prothrombin time (PT) =1.5× ULN and activated
partial thromboplastin time =1.5× ULN.Participants taking anticoagulants may be
included on a stable dose with a therapeutic INR <3.5. .
11. Patient must have a negative serum pregnancy test within 72 hours of the first dose of
study medication, unless they are of non-childbearing potential. If a negative result
cannot be confirmed by a urine test, a serum pregnancy test is required.
Non-childbearing potential is defined as follows:
1. Patient is = 45 years of age and has not had menses for > 1 year.
2. A follicle-stimulating hormone value in the postmenopausal range upon screening
evaluation if amenorrhoeic for < 2 years without a hysterectomy and oophorectomy.
3. Post-hysterectomy, post-bilateral oophorectomy, or post-tubal ligation:
- Documented hysterectomy or oophorectomy must be confirmed with medical
records of the actual procedure or confirmed by an ultrasound, MRI, or CT
scan.
- Tubal ligation must be confirmed with medical records of the actual
procedure.
- Information must be captured appropriately within the site's source
documents.
12. Patient of childbearing potential must agree to use a highly effective method of
contraception with their partners starting from time of consent through 180 days after
the last dose of study treatment. Note: Abstinence is acceptable if this is the
established and preferred contraception for the patient (Information must be captured
appropriately within the site's source documents).
Exclusion Criteria:
1. Patient has had = 6 prior lines of chemotherapy. Surgery of the recurrence is allowed.
2. Patient has received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent.
3. Patient has received prior anticancer therapy (chemotherapy, targeted therapies,
hormonal therapy, radiotherapy) within 21 days or < 5 times the half-life of the most
recent therapy prior to Study Day 1, whichever is shorter.
Note: Palliative radiation therapy to a small field = 1 week prior to Day 1 of study
treatment may be allowed after discussion with the SPONSOR.
4. Patient with contraindication to chemotherapy or immune checkpoint inhibitor
treatments or anti-angiogenic inhibitor
5. Patients with uncontrolled hypertension (defined as systolic blood pressure = 160 mmHg
and/or diastolic blood pressure =100 mmHg) based on an average of = 3 BP readings on =
2 sessions.
6. Patients with evidence of bleeding diathesis or significant coagulopathy (in the
absence of therapeutic anticoagulation)
7. Patients with current abdominal/pelvic fistula
8. Patient has a concomitant malignancy, or patient has a prior non-gynecological
malignancy who has been disease-free for < 3 years or who received any active
treatment in the last 3 years for that malignancy. Non-melanoma skin cancer is
allowed.
9. Patient has known uncontrolled central nervous system metastases, carcinomatosis
meningitis, or both. Note: Patients with previously treated brain metastases may
participate provided they are stable (without evidence of disease progression by
imaging [using the identical imaging modality for each assessment, either MRI or CT
scan] for at least 4 weeks prior to the first dose of study treatment and any
neurologic symptoms have returned to baseline), have no evidence of new or enlarging
brain metastases, and have not been using steroids for at least 7 days prior to study
treatment. Carcinomatous meningitis precludes a patient from study participation
regardless of clinical stability.
10. Patient has a known history of human immunodeficiency virus (HIV; HIV ½ antibodies).
Participants with known human immunodeficiency virus(HIV) are allowed if they meet all
of the following criteria:
- Cluster of differentiation 4(CD4) =350/µL and viral load <50 copies/mL.
- No history of acquired immunodeficiency syndrome-defining opportunistic
infections within 12 months before enrollment.
- No history of HIV-associated malignancy for the past 5 years.
- Concurrent antiretroviral therapy as per the most current National Institutes of
Health (NIH) Guidelines for the Use of Antiretroviral Agents in Adults and
Adolescents with HIV started >4 weeks before study enrollment.
11. Patient with presence of hepatitis B surface antigen or a positive hepatitis C
antibody test result at screening or within 3 months before first dose of dostarlimab
treatment.
- Participants who are hepatitis B surface antigen positive may be enrolled if
their HBV-DNA level is below the institutional lower limit.
- Participants with chronic hepatitis B virus (HBV) infection who meet the criteria
for anti-HBV therapy may be eligible if the participant is on a suppressive
antiviral therapy before initiation of cancer therapy.
- Participants with positive hepatitis C antibody due to prior resolved disease can
be enrolled only if a confirmatory negative hepatitis C RNA polymerase chain
reaction is obtained. Hepatitis C participants may be eligible if they both have
completed curative therapy and have a hepatitis C viral load <!-- Not Allowed Tag
Filtered --><quantifiable limit.
12. Patient has an active autoimmune disease that required systemic treatment in the past
2 years. Replacement therapy is not considered a form of (eg, thyroid hormone or
insulin).
13. diagnosis immunodeficiency receiving steroid any other immunosuppressive within 7 days
prior to first dose study treatment. Patients who have received acute and>/or low-dose
systemic immunosuppressive medications (e.g,, a one-time dose of dexamethasone for
nausea or chronic use of = 10 mg/day of prednisone or dose equivalent corticosteroid)
may be enrolled in the study after discussion with and approval by the Sponsor. The
use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) is
allowed.
14. Patient has not recovered (to Grade = 1) from previous anti-cancer therapy-induced
adverse events (AEs).
Note: Patients with Grade = 2 neuropathy, Grade = 2 alopecia, or Grade = 2 fatigue are
an exception to this criterion and may qualify for the study.
15. Patient has not recovered adequately from AEs or complications from any major surgery
prior to starting therapy. Major surgical procedures, other than for diagnosis, within
4 weeks prior to initiation of study treatment
16. Patient has a known hypersensitivity to bevacizumab or dostarlimab components or
excipients.
17. Patient is currently participating and receiving study treatment or has participated
in a study of an investigational agent and received study treatment or used an
investigational device within 4 weeks of the first dose of treatment.
18. Patient is considered a poor medical condition due to a serious, uncontrolled medical
disorder, non-malignant systemic disease, or active infection requiring systemic
therapy. Specific examples include, but are not limited to, active, non-infectious
pneumonitis; uncontrolled ventricular arrhythmia; recent (within 90 days) myocardial
infarction; uncontrolled major seizure disorder; unstable spinal cord compression;
superior vena cava syndrome; or any psychiatric or substance abuse disorders that
would interfere with cooperation with the requirements of the study (including
obtaining informed consent).
19. Patients with known history of non-infectious pneumonitis that required steroids or
has current pneumonitis.
20. Use of any of the following immunomodulatory agents within 28 days prior to the first
dose of study drug:
- Interferons
- Interleukins
- Live vaccine Note: Examples of live vaccines include, but are not limited to, the
following: measles, mumps, rubella, varicella/zoster, yellow fever, rabies, BCG,
and typhoid vaccine. mRNA and adenoviral-based COVID-19 vaccines are considered
non-live and are not exclusionary. Seasonal influenza vaccines for injection are
generally killed virus vaccines and are allowed as other killed vaccines, if done
at least 2 weeks prior the first dose of study drug; however, intranasal
influenza vaccines (eg, FluMist®) are live attenuated vaccines and are not
allowed.
21. Patient who are pregnant or lactating, or plan to become pregnant or lactate during
the expected duration of the study, from screening through 180 days after the last
dose of study drug.
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