Chronic Renal Insufficiency Clinical Trial
Official title:
Can the Peritoneal Cavity be a Source of Regulatory B Cells to Treat Auto-immune Disease?
Some subsets of lymphocytes are able to inhibit immune response and thus, could be used to control auto-immune diseases and transplant reject. In mice, the main source of those anti-inflammatory lymphocytes is the peritoneal cavity. No data are available in human. This study aims at exploring the presence of those anti-inflammatory lymphocytes in human peritoneal cavity and at determine how to expand those cells.
B cells will be collected during procedures planned for patients' standard care. Peritoneal
fluid and peripheral blood of patients will be collected during coelioscopy for exploration
of ovarian cysts or dialysis for treatment of chronic renal insufficiency.
Regulatory B cells (Breg cells) will be measured in peritoneal fluid and in peripheral blood
after in vitro stimulation and assessment of intracellular interleukin-10 by flow cytometry.
Proportion of Breg cells among B cells will be compared between peritoneal fluid and
peripheral blood in both groups.
Different protocols to induce differentiation of B cells into Breg cells will be tested and
compared.
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