Chronic Renal Insufficiency Clinical Trial
Official title:
COREV : A Multi-center, Randomized, Open-label Study Evaluating the Efficacy on Renal Function of Everolimus in Heart Transplant Recipients With Established Chronic Renal Failure
After transplantation, renal impairment, incidence and progression of atherosclerosis lead
to modification of immunosuppressive regimens, as switch, reduction or discontinuation of
CNI and/or introduction of everolimus. The risk or benefits of these strategies were not
clearly evaluated by specific clinical trials.
This study is specifically designed for evaluating the impact of everolimus introduction,
with calcineurin dose reduction, at less one year after cardiac transplantation, on renal
and clinical outcomes, specially on :
- Renal function improvement
- Vasculopathy and major cardiac event reduction
- Maintenance of immunosuppressive efficacy
n/a
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